A case of non-progressive congenital myopathy: Efficacy and clinical outcomes of the wharton's jelly derived mesenchymal stem cell transplantation
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Medical Sciences University of Teheran
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Non-Progressive Congenital Myopathy is a disease characterized by muscle weakness, and unfortunately, there is no conventional treatment. In the last decade, regenerative medicine practices have become a rising value, and Mesenchymal Stem Cells (MSCs) have fascinating outcomes in regenerative medicine with their high regenerative capacities, their ability to regulate with paracrine secretions, and their immunological properties. Based on our experience in our previous clinical studies, Wharton's-Jelly-derived (WJ-)MSCs are the most suitable source for muscle diseases among all MSC sources. In this study, we evaluated the outcomes of 10 doses of WJ-MSC transplantation to the patient diagnosed with Non-Progressive Congenital Myopathy. A 17-year-old female with a SPEN-1 mutation, Non-Progressive Congenital Myopathy patient received 10 times as 1×10?/kg in the intra-arterial, intramuscular and intravenous administration of allogenic WJ-MSC. Before and after the treatment, the patient was followed-up with the upper extremity scale, Vignos lower extremity scale, muscle strength scale, functional independence measure, and evaluation of Serum creatine kinase (CK) levels. Improvement in both upper extremity scale and Vignos lower extremity scales, increasing in muscle strength, and decreasing in CK-level were detected. Although transplantation of WJ-MSC cannot treat any genetic-based diseases, they may benefit in alleviating clinical outcomes of disease. More importantly, WJ-MSC transplantation may offer a better quality of life by alleviating the symptoms of this rare disease with no treatment option that can be provided in conventional methods. © 2022 Tehran University of Medical Sciences. All rights reserved.
Açıklama
Anahtar Kelimeler
Mesenchymal Stem Cells, Muscle Fibrosis, Muscle-Fiber Regeneration, Non-Progressive Congenital Myopathy
Kaynak
Acta Medica Iranica
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
60
Sayı
4
Künye
Azeri, R., Sun, E., & Karaoz, E. (2022). A case of non-progressive congenital myopathy: Efficacy and clinical outcomes of the wharton's jelly derived mesenchymal stem cell transplantation. Acta Medica Iranica, 60(4), 249-253. doi:10.18502/acta.v60i4.9270
