Evaluation of the relationship between bone marrow changes and hemogram findings in HIV-positive patients

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dc.authorscopusidMehmet Hilmi Doğu / 55212747300
dc.authorscopusidCeyda Aslan / 57190860900
dc.authorwosidMehmet Hilmi Doğu / W-2255-2017
dc.authorwosidCeyda Aslan / EMA-0305-2022
dc.contributor.authorKarışmaz, Abdulkadir
dc.contributor.authorCavdar, Vahit Can
dc.contributor.authorDoğu, Mehmet Hilmi
dc.contributor.authorAslan, Ceyda
dc.contributor.authorSarı, Nagehan Didem
dc.contributor.authorErdem Huq, Gülben
dc.contributor.authorEren, Rafet
dc.date.accessioned2025-04-17T08:32:33Z
dc.date.available2025-04-17T08:32:33Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractAim: This study aimed to evaluate the relationship between bone marrow (BM) changes and initial laboratory findings in Human immunodeficiency virus (HIV)-positive patients, focusing on hematopoietic system alterations such as myeloid hyperplasia, erythroid hyperplasia, and megakaryocyte activity. Materials and Methods: A total of 57 HIV-positive patients were included in this retrospective study. BM findings, including cellularity, plasma cell ratio, reticulin fiber ratio, and specific features such as myeloid and erythroid hyperplasia, were analyzed. Initial laboratory parameters, including white blood cell (WBC), hemoglobin (HGB), hematocrit (HCT), platelet, and CD4 counts, were assessed. Results: Significant positive correlations were observed between cellularity and WBC (r=0.40, p=0.005), monocyte (r=0.40, p=0.005), and CD8 counts (r=0.32, p=0.02). Plasma cell ratio showed negative correlations with HGB (r=-0.35, p=0.01), HCT (r=-0.35, p=0.01), and albumin (ALB) (r=-0.50, p<0.001). Reticulin fiber ratio was negatively correlated with WBC (r=-0.30, p=0.03), HGB (r=-0.32, p=0.02), and ALB (r=-0.35, p=0.008). Conclusion: BM changes in HIV-positive patients, such as myeloid and erythroid hyperplasia, are associated with significant alterations in peripheral blood parameters, highlighting the importance of comprehensive hematological evaluations in this population. These findings contribute to a better understanding of HIV-related hematopoietic dysfunction and its clinical implications
dc.identifier.citationKARIŞMAZ, A., ÇAVDAR, V. C., Mehmet Hilmi, D. O. Ğ. U., ASLAN, C., Nagehan Didem, S. A. R. I., HUQ, G. E., & Rafet, E. R. E. N. (2025). Evaluation of The Relationship Between Bone Marrow Changes and Hemogram Findings in HIV-Positive Patients. Evaluation, 13(1), 76-86.
dc.identifier.doi10.4274/nkmj.galenos.2025.29494
dc.identifier.endpage86
dc.identifier.issn2587-0262
dc.identifier.issue1
dc.identifier.startpage76
dc.identifier.urihttp://dx.doi.org/10.4274/nkmj.galenos.2025.29494
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6168
dc.identifier.volume13
dc.identifier.wosWOS:001441057000001
dc.indekslendigikaynakWeb of Science
dc.institutionauthorDoğu, Mehmet Hilmi
dc.institutionauthorAslan, Ceyda
dc.institutionauthoridMehmet Hilmi Doğu / 0000-0001-7237-2637
dc.language.isoen
dc.publisherGalenos publ house
dc.relation.ispartofNamık Kemal medical journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHIV
dc.subjectBone Marrow
dc.subjectMyeloid Hyperplasia
dc.subjectErythroid Hyperplasia
dc.subjectHematopoietic Dysfunction
dc.subjectLaboratory Findings
dc.titleEvaluation of the relationship between bone marrow changes and hemogram findings in HIV-positive patients
dc.typeArticle

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