Mesenchymal stem cells for the treatment of covid-19: why and when they should be used?

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dc.authoridHakan Darıcı / 0000-0001-9393-554Xen_US
dc.authoridEda Sun / 0000-0003-0320-5784en_US
dc.authoridDuygu Koyuncu Irmak / 0000-0002-3277-5535en_US
dc.authorscopusidHakan Darıcı / 22333489600
dc.authorscopusidEda Sun / 57225054414
dc.authorscopusidDuygu Koyuncu Irmak / 57219539042
dc.authorwosidHakan Darıcı / AAG-4316-2019
dc.authorwosidEda Sun / GER-0120-2022
dc.authorwosidErdal Karaöz / AAO-1470-2020
dc.contributor.authorDarıcı, Hakan
dc.contributor.authorSun, Eda
dc.contributor.authorIrmak, Duygu Koyuncu
dc.contributor.authorKaraöz, Erdal
dc.date.accessioned2021-07-13T06:56:12Z
dc.date.available2021-07-13T06:56:12Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractCOVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which caused deaths of more than 300.000 people around the world within the first few months of 2020. SARS-CoV-2 uses ACE2 receptors to infect respiratory system cells and may cause pneumonia and severe lung damage. The virus can also spread other organs rapidly via ACE2 expressing endothelial cells and cause coagulopathy, and further damage to the organs. Another and probably more harmful effect of the virus is the overreaction of the immune system leading to hyperinflammation causing multiple organ failure and death. Therefore COVID-19 can be considered as a viral infection causing auto-immune disorders. Currently, no vaccine or effective pharmacological treatment established for the disease. On the other hand, Mesenchymal Stem Cells (MSCs) possess anti- inflammatory and immune-regulatory effects along with their regenerative abilities. In this article, we thoroughly evaluate the COVID-19 pandemic and the damage mechanisms on the cellular level which can be ameliorated with the cellular therapies. We also gathered previous and ongoing stem cell clinical trial data from diseases with similar symptoms. All these accumulated data and current clinical trial results indicate that the cellular therapies could be the most effective treatment option for COVID-19 patients to ameliorate the damaged tissues and save lives.en_US
dc.identifier.citationDarici H., Sun E., Irmak D.K., & Karaoz E. (2021). Mesenchymal stem cells for the treatment of covid-19: Why and when they should be used?, 4(15), 159-181.en_US
dc.identifier.endpage181en_US
dc.identifier.issn1556-8539en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage159en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1916
dc.identifier.volume15en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorDarıcı, Hakan
dc.institutionauthorSun, Eda
dc.institutionauthorKoyuncu Irmak, Duygu
dc.institutionauthorKaraöz, Erdal
dc.language.isoenen_US
dc.publisherNova Science Publishersen_US
dc.relation.ispartofJournal of Stem Cellsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleMesenchymal stem cells for the treatment of covid-19: why and when they should be used?en_US
dc.typeArticleen_US

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