Changes In Various Hormone Levels In The Rabbit Traumatic Facial Nerve Injury Model

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dc.contributor.authorGöçmen, Ayşe Yeşim
dc.contributor.authorDağlıoğlu, Yusuf Kenan
dc.contributor.authorKapusuz, Zeliha
dc.contributor.authorÖzkırış Özkırış, Mahmut
dc.contributor.authorGence, Muzaffer
dc.date.accessioned2024-05-19T14:23:38Z
dc.date.available2024-05-19T14:23:38Z
dc.date.issued2018
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjectives: We aimed to look into potential associations betweenspecific biomarkers and trauma to Cranial Nerve VII (CNVII) in a rabbitmodel, focusing on whether endocrine studies have potential as biomarkers in this context.Methods: 30 adult New Zealand rabbits with intact facial muscleswere used for the research. Each animal underwent identical surgeryby the same surgeon. The facial nerve divisions were exposed by incising below the level of the mandible. After dissection of the skin andsubcutaneous layers, the buccal division of CNVII was located with thenerve stimulator and microscopic dissection and a section of nerve10mm long was excised in each case from the buccal branch of CNVII.Blood samples were drawn 8 weeks and 12 weeks after nerve injuryhad been surgically induced. The samples from day 1, week 4 andweek 8 were tested for the following levels: Testosterone, oestrogen,progesterone, free T3 and T4, Cancer antigen 19-9 (Ca19-9), folate,TPSA, FPSA, FSH, LH, CA15.3, CAE, AFP and prolactin.Results: The levels of free T3 and T4 as well as testosterone, weredown at 4th week, but at 8 weeks each had increased. Ca19-9 levelswere also above the baseline. At 4 weeks, whilst oestrogen had markedly risen, progesterone had fallen. The statistical significance of thechange in levels of free T3 and T4, testosterone, oestrogen, progesterone and FPSA was evaluated. For the group of animals with inducedparalysis, the association between the lesion and testosterone, oestrogen, progesterone, free T3 and T4, Ca19-9, and folate levels werestrong and at the level of statistical significance.Conclusion: There were statistically significant alterations in the serum levels of free T3 and T4, testosterone, oestrogen, progesteroneand FPSA at the 4 and 8 week intervals post surgically-induced CNVII injury. It is likely that rabbit pathophysiology resembles humanpathophysiology in nervous injury, hence these six biomarkers may beof value in managing trauma or idiopathic degeneration of CNVII inhumans. The authors hope this study will pave the way for future research in this areaen_US
dc.identifier.doi10.32448/entupdates.458996
dc.identifier.endpage92en_US
dc.identifier.issn2149-7109
dc.identifier.issn2149-6498
dc.identifier.issue2en_US
dc.identifier.startpage88en_US
dc.identifier.trdizinid390293en_US
dc.identifier.urihttps://doi.org/10.32448/entupdates.458996
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/390293
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4067
dc.identifier.volume8en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofENT Updatesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.titleChanges In Various Hormone Levels In The Rabbit Traumatic Facial Nerve Injury Modelen_US
dc.typeArticleen_US

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