Antibacterial and antifungal activities of isoquinoline alkaloids of the Papaveraceae and Fumariaceae families and their implications in structure–activity relationships

Basit Öğe Kaydı
dc.authoridGizem Gülsoy Toplan / 0000-0002-0544-2532
dc.authorscopusidGizem Gülsoy Toplan / 57192304526
dc.authorwosidGizem Gülsoy Toplan / EYL-0628-2022
dc.contributor.authorAvcı, Fatma Gizem
dc.contributor.authorAtas, Başak
dc.contributor.authorGülsoy Toplan, Gizem
dc.contributor.authorGürer, Ça?layan Unsal
dc.contributor.authorSarıyar Akbulut, Berna
dc.date.accessioned2021-08-07T07:17:01Z
dc.date.available2021-08-07T07:17:01Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractHistorically, plants with a wide range of natural products they possess have long served as important sources of therapeutical agents. Unfortunately, progress in the construction of synthetic chemical libraries shifted the trend from natural products. With rising resistance to available antibacterial and antifungal agents, natural products are now regaining their attention. They represent an ideal platform for antimicrobial drug discovery, due to their structural complexity, functional group density, and the evolved ability to penetrate the bacterial cell envelope. Plant alkaloids are among these natural products with novel structures and significant bioactivities. Following a detailed comparative analysis of the reported antimicrobial activities of the alkaloids derived from benzyltetrahydroisoquinoline alkaloids of two closely related plant families: Papaveraceae and Fumariaceae, we specifically focus on some structural aspects of antimicrobial activities of these alkaloids. Overall, tetrahydroprotoberberines are commonly weaker agents than their corresponding protoberberines. While methylation enhances activity, the reduction of a molecule results in activity loss. Furthermore, alkaloid charge could be an important issue in enhancing the interactions with the membranes. Our findings indicated that although a large number of studies focus on antimicrobial activities is huge, the number of microorganisms tested is highly variable. The generalizations can be poor if the strains tested are different.en_US
dc.identifier.citationAvci, F. G., Atas, B., Toplan, G. G., Gurer, C., & Akbulut, B. S. (2021). Antibacterial and antifungal activities of isoquinoline alkaloids of the Papaveraceae and Fumariaceae families and their implications in structure–activity relationships. In Studies in Natural Products Chemistry (Vol. 70, pp. 87-118). Elsevier.en_US
dc.identifier.doi10.1016/B978-0-12-819489-8.00016-8en_US
dc.identifier.endpage118en_US
dc.identifier.issn1572-5995en_US
dc.identifier.scopus2-s2.0-85111005349en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage87en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-12-819489-8.00016-8
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1975
dc.identifier.volume70en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGülsoy Toplan, Gizem
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofStudies in Natural Products Chemistryen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobialen_US
dc.subjectFumariaceaeen_US
dc.subjectIsoquinoline Alkaloidsen_US
dc.subjectPapaveraceaeen_US
dc.subjectStructure–Activity Relationshipen_US
dc.titleAntibacterial and antifungal activities of isoquinoline alkaloids of the Papaveraceae and Fumariaceae families and their implications in structure–activity relationshipsen_US
dc.typeBook Chapteren_US

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Eczacılık Meslek Bilimleri Bölümü Makale Koleksiyonu