Assessment of Centella Asiatica Extract Containing Dual-crosslinked Gel-MA/Pec Hydrogels as Wound Dressing

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dc.contributor.authorAklar, Demet Akalgan
dc.contributor.authorAlbayrak, Betül
dc.contributor.authorGelal, Melisa
dc.contributor.authorİzbudak, Burçin
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorÖztürk, Ayça Bal
dc.date.accessioned2024-05-19T14:23:34Z
dc.date.available2024-05-19T14:23:34Z
dc.date.issued2022
dc.departmentİstinye Üniversitesien_US
dc.description.abstractIn the present work, 3D-printed wound dressings containing different amounts of Centella Asiatica (CA) extract were synthesized via dual-crosslinking method. Methacrylic anhydride modified gelatin (Gel-MA) and pectin (Pec) were chosen as the base material for dressings. A dual crosslinked network was formed with Gel-MA photo-crosslinking using Irgacure 2959 and Pectin (Pec) psychical-crosslinking using Ca++ ions. Meanwhile, the developed dual-crosslinked hydrogel dressings were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and mechanical, swelling, in vitro degradation as well as ex vivo bioadhesion tests. As the amount of CA in the dressing hydrogels increased, the degradation rates increased. In addition, the prepared dressings provide good bioadhesion on the chicken skin. Moreover, (3-(4,5-Dimethylthiazol- 2-yl)-2,5-Diphenyltetrazolium Bromide) (MTT) assay revealed cell viability of Gel-MA/ Pec hydrogel dressings containing CA extract. The results presented the dressings as a promising biomaterial to be used for wound healing purposes, which should be further investigated in future.en_US
dc.identifier.doi10.17350/HJSE19030000282
dc.identifier.endpage294en_US
dc.identifier.issn2149-2123
dc.identifier.issn2148-4171
dc.identifier.issue4en_US
dc.identifier.startpage287en_US
dc.identifier.trdizinid1175585en_US
dc.identifier.urihttps://doi.org/10.17350/HJSE19030000282
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1175585
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4033
dc.identifier.volume9en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofHittite Journal of Science and Engineeringen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.titleAssessment of Centella Asiatica Extract Containing Dual-crosslinked Gel-MA/Pec Hydrogels as Wound Dressingen_US
dc.typeArticleen_US

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