Histopathological diagnoses revealed by indication-based renal allograft biopsies: a retrospective analysis

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dc.contributor.authorEren, Eryiğit
dc.contributor.authorTokaç, Mehmet
dc.contributor.authorAydın, Alaaddin
dc.contributor.authorŞahin, Taylan
dc.contributor.authorDinçkan, Ayhan
dc.contributor.authorUslu, Hikmet Bora
dc.contributor.authorAlkan, Selman
dc.date.accessioned2024-05-19T14:23:35Z
dc.date.available2024-05-19T14:23:35Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjectives: Although there have been several advances in post-solid organ transplantation immunosuppression medications over the last two decades, the long-term survival of renal allografts did not significantly improve. Renal allograft biopsy is a helpful tool for determining the cause of graft dysfunction and adjusting patient management. Methods: Patients who received kidney transplantation and underwent allograft biopsy in Istinye University Hospital between January 2017 and January 2023 constituted the target population of this study. Demographic parameters, clinical data and biopsy indications, and histopathological assessment results of the patients were retrospectively analyzed. Results: Overall, 74 patients were included. The histopathology results included acute T-Cell mediated rejection (TCMR) (n = 15, 20%), tubular atrophy/chronic allograft nephropathy (IFTA) (n = 11, 15%), calcineurin inhibitor (CNI) toxicity (n = 2, 3%), chronic antibody-mediated rejection (ABMR) (n = 2, 3%), borderline pathology (n = 10, 13.5%), normal histology (n = 5, 6.5%), transplant glomerulopathy (TG) (n = 5, 6.5%), acute ABMR (n = 4, 5%), acute tubular necrosis (n = 7, 9%), polyomavirus nephropathy (n = 3, 4%) and non-specific changes (n = 10, 13.5%). The C4d was positive in 12% (n = 9) of the graft biopsies. In 73% (n = 54) of cases, the treatment strategy was changed based on biopsy results. Among all patients, 19 (25.6%) lost their grafts during follow-up. Conclusions: According to the histopathological analysis results, acute TCMR, IFTA, and borderline pathology were the most common causes of renal graft dysfunction. Renal allograft biopsy led to a remarkable change in treatment strategies in a significant number of cases.en_US
dc.identifier.doi10.18621/eurj.1330877
dc.identifier.endpage1244en_US
dc.identifier.issn2149-3189
dc.identifier.issue5en_US
dc.identifier.startpage1240en_US
dc.identifier.trdizinid1194902en_US
dc.identifier.urihttps://doi.org/10.18621/eurj.1330877
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1194902
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4039
dc.identifier.volume9en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofThe European Research Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.titleHistopathological diagnoses revealed by indication-based renal allograft biopsies: a retrospective analysisen_US
dc.typeArticleen_US

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