Association between Mannose-Binding Lectin 2 Gene Polymorphism and Liver Fibrosis in Patients with Chronic Viral Hepatitis

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dc.contributor.authorEminler, A. T.
dc.contributor.authorKarkucak, M.
dc.contributor.authorGurel, S.
dc.contributor.authorAyyildiz, T.
dc.contributor.authorGulten, T.
dc.contributor.authorIrak, K.
dc.contributor.authorYakut, T.
dc.date.accessioned2024-05-19T14:41:33Z
dc.date.available2024-05-19T14:41:33Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjective: Mannose-binding lectin (MBL) has become a popular molecule in investigations on basic and clinical gastroenterology and contributed to new approaches to the understanding of infectious and immune diseases associated with intestine and liver. The aim of the present study was to investigate the association between codon 54 polymorphisms in MBL2 gene coding MBL and predisposition to fibrosis in patients with viral hepatitis B and C. Methods: One hundred patients with chronic hepatitis (70 hepatitis B, 30 hepatitis C) who underwent liver biopsy and 100 healthy controls with no known chronic disease were included in the study. Patients in both viral hepatitis groups were divided into two groups according to their fibrosis scores with Ishak scoring system. The polymerase chain reaction-restriction fragment length polymorphism method was applied to determine the MBL2 codon 54 polymorphisms. For the statistical analysis, the level of significance was set at p < 0.05. Results: No significant differences in allele frequencies for any polymorphism were observed between patients and controls, although the G allele was more frequent in the patient groups (p > 0.05). In the comparison in terms of G and A alleles between two groups, hepatitis B patients in Group-II (group with high fibrosis score) were found to have a significantly higher frequency of A alleles (p = 0.027). Conclusion: Although it is accepted that MBL2 polymorphism plays a part during hepatitis B virus and hepatitis C virus infections, larger studies investigating the relation between MBL2 polymorphism and disease progression, and treatment are required.en_US
dc.identifier.doi10.7727/wimj.2016.155
dc.identifier.endpage12en_US
dc.identifier.issn0043-3144
dc.identifier.issn2309-5830
dc.identifier.issue1en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org10.7727/wimj.2016.155
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5126
dc.identifier.volume70en_US
dc.identifier.wosWOS:001111167400003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherUniv West Indies Faculty Medical Sciencesen_US
dc.relation.ispartofWest Indian Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectFibrosisen_US
dc.subjectHepatitis Ben_US
dc.subjectHepatitis Cen_US
dc.subjectMbl2 Geneen_US
dc.subjectPolymorphismen_US
dc.titleAssociation between Mannose-Binding Lectin 2 Gene Polymorphism and Liver Fibrosis in Patients with Chronic Viral Hepatitisen_US
dc.typeArticleen_US

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