Potential Applications of Photobiomodulation in Combinatorial Cancer Therapy: Developments in Diagnosis and Treatment

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dc.contributor.authorAy, E.N.
dc.contributor.authorAcar, D.H.
dc.contributor.authorKaleağasioğlu, F.
dc.date.accessioned2024-05-19T14:33:37Z
dc.date.available2024-05-19T14:33:37Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjective: Over the last two decades, the potential applications of photobiomodulation therapy (PBMT) have garnered increas-ing attention. The mechanism of PBMT involves the absorption of light energy by cellular components, such as chromophores. This absorption initiates a cascade of biochemical reactions, including cellular signaling pathways, gene expression, and the production of various molecules such as reactive oxygen species, adenosine triphosphate, and growth factors. In this review, we aimed to investigate the potential applications of PBMT when combined with chemotherapy (CT), radiotherapy (RT), and immunotherapy. Material and Methods: PubMed (National Library of Medicine, ABD), Scopus (Elsevier, Hollanda), and Google Scholar (Google, ABD) were searched to obtain data. Results: Based on the results of in vitro and in vivo studies, PBMT acts as a chemo-and radio-sensitizer. It facilitates dose reduction and, notably, does not decrease but may increase the viability of noncancer cells. This property enables the protection of noncancerous cells against antineoplastic CT-related toxi-city. The important factor in effectively employing PBMT for cancer treatment depends on selecting the correct dosage, including wavelength, power density, energy density, and exposure time. The accumulating evidence supporting the benefits of PBMT has led to its recommendation by the World Association for Laser Therapy for managing CT-related adverse effects. Conclusion: PBMT is a promising strategy for the combination therapy of cancer. Nevertheless, further studies are warranted to establish the precise protocols for PBMT. These studies are essential to address its limitations and uncover the benefits of light therapy that have not yet been fully explored. © 2024 by Turkish Society of Medical Oncology.en_US
dc.identifier.doi10.37047/jos.2023-99295
dc.identifier.endpage59en_US
dc.identifier.issn2651-4532
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85188254855en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.37047/jos.2023-99295
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4288
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofJournal of Oncological Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectChemotherapyen_US
dc.subjectİmmunotherapyen_US
dc.subjectLow Level Laser Therapyen_US
dc.subjectRadiotherapyen_US
dc.titlePotential Applications of Photobiomodulation in Combinatorial Cancer Therapy: Developments in Diagnosis and Treatmenten_US
dc.typeReview Articleen_US

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