Histomorphological features of atypical small acinar proliferations (ASAP) that favor malignancy

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dc.authoridSibel Şensu / 0000-0002-4607-780Xen_US
dc.authorscopusidSibel Şensu / 35746731800
dc.authorwosidSibel Şensu / AGU-9782-2022
dc.contributor.authorSade, Ayşe Gökçen
dc.contributor.authorSarıkaya, Şükran
dc.contributor.authorÖzdemir Barışık, Nagehan
dc.contributor.authorBarışık, Cem Cahit
dc.contributor.authorŞensu, Sibel
dc.date.accessioned2022-02-08T06:25:53Z
dc.date.available2022-02-08T06:25:53Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Cases diagnosed as atypical small acinar proliferation (ASAP) in prostate transrectal ultrasound (TRUS) biopsies typically require rebiopsies, which are invasiveand associated with increased risk of complications. Therefore, reduction in the rates of ASAP diagnoses during initial biopsy interpretation will decrease the need forrebiopsy and limit the burden of new diagnostic procedures. The current study aimed to investigate patient demographics, serum PSA levels, and histopathological features of cases identified as “ASAP” during initial prostate biopsies and as “benign” or “malignant” in the rebiopsies. Methods: This retrospective study included 187 cases and 257 core biopsies with a diagnosis of ASAP. Initial age and serum PSA levels were recorded, and the cores were analyzed histopathologically. The presence of nuclear enlargement, prominence of nucleoli, cytoplasmic amphophilia, luminal acellular secretions, cristalloids, infiltrative growth pattern, atrophy, inflammation, and number of the suspicious acini were recorded. Adenocarcinomas were identified using the Gleason score. Results: The mean age and serum PSA levels were significantly higher in the intermediate- high grade malignant group compared to the other groups, while nuclear enlargement (>2 times) and prominent nucleoli were more frequently observed in the malignant group compared to the benign group. Amphophilic cytoplasm and luminal acellular amorphous eosinophilic secretions were more frequently observed in malignant groups, while the benign group exhibited higher rates of inflammation. Conclusion: The findings of the current study showed enlargement of the nuclei (?2 times), nucleolar prominence, amphophilic cytoplasm, luminal amorphous acellular secretion, and absence of inflammation were associated with malignancy. Moreover, higher mean age and serum PSA level were related with intermediate-high grade malignancy, and consideration of these factors during evaluation of initial TRUS biopsies may decrease the prevalence of ASAP diagnoses and prevent unnecessary interventions.en_US
dc.identifier.citationSADE A. G,SARIKAYA Ş,BARIŞIK N. Ö,BARIŞIK C. C,ŞENSU S (2020). Histomorphological Features of Atypical Small Acinar Proliferations (ASAP) That Favor Malignancy. Southern Clinics of Istanbul Eurasia, 31(4), 382 - 387. Doi: 10.14744/scie.2020.83097en_US
dc.identifier.doi10.14744/scie.2020.83097en_US
dc.identifier.endpage387en_US
dc.identifier.issn2587-0998en_US
dc.identifier.issn2587-1404en_US
dc.identifier.issue4en_US
dc.identifier.startpage382en_US
dc.identifier.trdizinid486707en_US
dc.identifier.urihttps://doi.org/10.14744/scie.2020.83097
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2474
dc.identifier.volume31en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorŞensu, Sibel
dc.language.isoenen_US
dc.relation.ispartofSouthern Clinics of Istanbul Eurasiaen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtypical Small Acinar Proliferationen_US
dc.subjectPrognosisen_US
dc.subjectProstateen_US
dc.subjectTRUS Biopsyen_US
dc.titleHistomorphological features of atypical small acinar proliferations (ASAP) that favor malignancyen_US
dc.typeArticleen_US

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