Design of poly(vinyl pyrrolidone) and poly(ethylene glycol) microneedle arrays for delivering glycosaminoglycan, chondroitin sulfate, and hyaluronic acid

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dc.authorscopusidGüralp Özkoç / 6602128118
dc.authorwosidGüralp Özkoç / F-7917-2018
dc.contributor.authorChoupani, Andisheh
dc.contributor.authorTemuçin, Elif Şevval
dc.contributor.authorÇiftçi Eda
dc.contributor.authorBakan, Feray
dc.contributor.authorÇamiç, Büşra Tuğba
dc.contributor.authorÖzkoç, Güralp
dc.contributor.authorSezen, Meltem
dc.contributor.authorKorkusuz, Petek
dc.contributor.authorKorkusuz, Feza
dc.contributor.authorBediz, Bekir
dc.date.accessioned2025-04-18T08:51:09Z
dc.date.available2025-04-18T08:51:09Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Bölümü
dc.description.abstractOsteoarthritis (OA) is a prevalent joint disorder characterized by cartilage and bone degradation. Medical therapies like glucosaminoglycan (GAG), chondroitin sulfate (CS), and hyaluronic acid (HA) aim to preserve joint function and reduce inflammation but may cause side effects when administered orally or via injection. Microneedle arrays (MNAs) offer a localized drug delivery method that reduces side effects. Thus, this study aims to demonstrate the feasibility of delivering GAG, CS, and HA using microneedles in vitro. An optimal needle geometry is crucial for the successful application of MNA. To address this, here we employ a multi-objective optimization framework using the non-dominated sorting genetic algorithm II (NSGA-II) to determine the ideal MNA design, focusing on preventing needle failure. Then, a three-step fabrication approach is followed to fabricate the MNAs. First, the master (male) molds are fabricated from poly(methyl methacrylate) using mechanical micromachining based on optimized needle geometry. Second, a micro-molding with Polydimethylsiloxane (PDMS) is used for the fabrication of production (female) molds. In the last step, the MNAs were fabricated by microcasting the hydrogels using the production molds. Light microscopy (LIMI) confirms the accuracy of the MNAs manufactured, and in vitro skin insertion tests demonstrate failure-free needle insertion. Subsequently, we confirmed the biocompatibility of MNAs by evaluating their impact on the L929 fibroblast cell line, human chondrocytes, and osteoblasts. © 2024 Informa UK Limited, trading as Taylor & Francis Group.
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under Grant No. 120R022 (PI: Bekir Bediz). Feza Korkusuz, MD is an active member of the Turkish Academy of Sciences (T\u00DCBA).
dc.identifier.citationChoupani, A., Temucin, E. S., Ciftci, E., Bakan, F., Camic, B. T., Ozkoc, G., ... & Bediz, B. (2025). Design of poly (vinyl pyrrolidone) and poly (ethylene glycol) microneedle arrays for delivering glycosaminoglycan, chondroitin sulfate, and hyaluronic acid. Journal of Biomaterials Science, Polymer Edition, 36(1), 64-85.
dc.identifier.doi10.1080/09205063.2024.2392914
dc.identifier.endpage85
dc.identifier.issn09205063
dc.identifier.issue1
dc.identifier.pmid39264737
dc.identifier.scopus2-s2.0-85204107169
dc.identifier.scopusqualityQ1
dc.identifier.startpage64
dc.identifier.urihttp://dx.doi.org/10.1080/09205063.2024.2392914
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6629
dc.identifier.volume36
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkoç, Güralp
dc.institutionauthoridGüralp Özkoç / 0000-0002-3194-5256
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofJournal of Biomaterials Science, Polymer Edition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitak120R022
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChondroitin Sulfate
dc.subjectGlycosaminoglycan
dc.subjectHyaluronic Acid
dc.subjectMicroneedle
dc.subjectMicroneedle Array
dc.subjectNeedle Geometry Optimization
dc.titleDesign of poly(vinyl pyrrolidone) and poly(ethylene glycol) microneedle arrays for delivering glycosaminoglycan, chondroitin sulfate, and hyaluronic acid
dc.typeArticle

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