Emergence of Drug-Resistant Pathogens in a Neonatal Intensive Care Unit

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dc.authoridAYDINLI, AYDIN/0000-0003-1769-331X
dc.authorwosidAYDINLI, AYDIN/AAV-6299-2020
dc.contributor.authorAydinli, Aydin
dc.contributor.authorSertel Selale, Deniz
dc.contributor.authorKaya, Ayse Demet
dc.date.accessioned2024-05-19T14:39:30Z
dc.date.available2024-05-19T14:39:30Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjective Neonatal bloodstream infections (BSIs) due to drug-resistant pathogens are a major cause of neonatal morbidity and mortality. Unfortunately, data regarding the pathogens and their resistance profile are limited in developing countries. The aim of this study was to determine the bacteriological profile and antimicrobial susceptibility patterns in neonatal BSI at a university hospital in Turkiye.Methods Medical records of neonates with suspected sepsis were retrospectively reviewed during the study period (between January 1, 2018, and December 31, 2020) for demographic data, blood culture, and antimicrobial susceptibility test results.Results During the study period, 117 BSI episodes were encountered in 106 neonates. The most common pathogen isolated was Staphylococcus epidermidis ( n = 86, 73.5%), followed by Klebsiella pneumoniae ( n = 11, 9.4%). Methicillin resistance among staphylococci (77/93, 82.8%) and extended-spectrum beta-lactamase (ESBL) production among Enterobacterales (14/17, 82.4%) were common. Gentamicin resistance was detected in 70.1% (54/77) of methicillin-resistant staphylococci and 78.6% (11/14) of ESBL (+) Enterobacterales. Vancomycin and colistin resistance were not detected.Conclusion The high rate of resistant pathogens encountered in neonatal BSIs underline the importance of constant surveillance of the local pathogens and their antimicrobial susceptibility patterns, which is crucial for implementing appropriate therapy that could save lives and lower the burden of antimicrobial resistance.en_US
dc.identifier.doi10.1055/s-0043-1775838
dc.identifier.endpage330en_US
dc.identifier.issn1305-7707
dc.identifier.issn1305-7693
dc.identifier.issue6en_US
dc.identifier.startpage326en_US
dc.identifier.urihttps://doi.org10.1055/s-0043-1775838
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4794
dc.identifier.volume18en_US
dc.identifier.wosWOS:001085881000008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofJournal of Pediatric Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBloodstream Infectionen_US
dc.subjectNeonatal Sepsisen_US
dc.subjectBlood Cultureen_US
dc.subjectAntibiotic Resistanceen_US
dc.subjectNeonatal Icuen_US
dc.titleEmergence of Drug-Resistant Pathogens in a Neonatal Intensive Care Uniten_US
dc.typeArticleen_US

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