Effectiveness of tDCS blinding protocol in a sham-controlled study

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dc.authoridSacit Karamürsel / 0000-0002-7534-9392
dc.authorscopusidSacit Karamürsel / 7004361830
dc.authorwosidSacit Karamürsel / O-9371-2019
dc.contributor.authorDinn, W.
dc.contributor.authorGöral, F.
dc.contributor.authorAdıgüzel, S.
dc.contributor.authorKaramürsel, Sacit
dc.contributor.authorFregni, F.
dc.contributor.authorAyçiçeği-Dinn, A.
dc.date.accessioned2021-10-28T08:23:11Z
dc.date.available2021-10-28T08:23:11Z
dc.date.issued2017en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThere are surprisingly few studies investigating the effectiveness of transcranial direct current stimulation (tDCS) blinding protocols. The objective of the present study was to determine whether a commonly used DC stimulator (neuroConn, Ilmenau, Germany) effectively blinds subjects participating in a single trial, double-blind/sham-controlled protocol. We investigated the question by analyzing blinding assessment in a double-blinded tDCS memory trial. Findings from that trial will be reported elsewhere (i.e., separate abstract submitted to the brain stimulation conference). Subjects were instructed to indicate whether they received 20 minutes of active- or sham-tDCS to determine whether blinding was successful. Participants were informed prior to the stimulation session that they would be assigned to an active- or sham-tDCS group. University students were assigned to genuine-tDCS (n = 27) or sham-tDCS (n = 26) groups. Subjects in the active-tDCS group underwent left DLPFC anodal/right frontopolar cathodal stimulation during a single tDCS session (2 mA, 20 minutes duration). During the sham session, genuine tDCS was delivered for the initial 30 seconds of the 20 minute session. The initial scalp sensations associated with tDCS (e.g., tingling) were experienced by participants receiving sham stimulation. Thus, the subject should be unaware of his/her group assignment. Analysis revealed that 29 of 53 subjects (54.7 %) correctly identified group assignment (binomial test, p = .58). 22 of 27 subjects (81.4 %) in the active-tDCS group correctly identified group assignment (i.e., believed that they had received genuine tDCS), while only 7 of 26 (26.9%) participants in the sham group correctly identified group assignment (i.e., stated that they had received “sham” stimulation). Thus, 19 of 26 participants (73.0 %) assigned to the sham group believed that they had received genuine tDCS. Results support the use of the current blinding protocol in single trial, sham-controlled tDCS studies.en_US
dc.identifier.citationDinn, W., Göral, F., Adigüzel, S., Karamürsel, S., Fregni, F., & Aycicegi-Dinn, A. (2017). Effectiveness of tDCS blinding protocol in a sham-controlled study. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 10(2), 401.en_US
dc.identifier.doi10.1016/j.brs.2017.01.188en_US
dc.identifier.endpage401en_US
dc.identifier.issn1935-861Xen_US
dc.identifier.issue2en_US
dc.identifier.startpage401en_US
dc.identifier.urihttps://doi.org/10.1016/j.brs.2017.01.188
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2195
dc.identifier.volume10en_US
dc.institutionauthorKaramürsel, Sacit
dc.language.isoenen_US
dc.publisherScience Directen_US
dc.relation.ispartofBrain Stimulationen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTranscranial Direct Current Stimulation (tDCS)en_US
dc.subjectBlinding Protocolen_US
dc.subjectEffectivenessen_US
dc.titleEffectiveness of tDCS blinding protocol in a sham-controlled studyen_US
dc.typeOtheren_US

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