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Öğe Neural underpinnings of negative emotional expressions evoked by audiovisual stimuli(SAGE PUBLICATIONS LTD, 2021) Türk, Dilara D.; Eskikurt, Gökçer; Taşlıyurt, Şule; Yıldırım, Funda[No Abstract Available]Öğe Comparison of intra operative and post implant plans for low dose rate prostate brachytherapy(ELSEVIER IRELAND LTD, 2021) Senkesen, O.; Kucucuk, H.; Goksel, E. O.; Tezcanli, E.; Ozen, Z.; Kucucuk, S.; Kemikler, G.; Dişçi, Rian; Aslay, I.We aimed to evaluate the post-implant dosimetry (PID) for low-dose rate (LDR) seed implantation for prostate cancer patients by comparing the dose volume histograms (DVH) between intraoperative (IOP) and post-implant plansÖğe TDCS and memory function among individuals with or without elevated ADHD symptoms(Science Direct, 2017) Aycicegi-Dinn, A.; Göral, F.; Adigüzel, S.; Karamürsel, Sacit; Dinn, W.We determined whether transcranial direct current stimulation (tDCS) improved memory function via strengthened executive control among university students with or without elevated scores on a measure of adult attention deficit-hyperactivity disorder (ADHD). The prediction that volunteers receiving left DLPFC anodal/right frontopolar cathodal stimulation would demonstrate improved executive control/memory function (determined by performance on California Verbal Learning Test-CVLT and Rey Complex Figure Test-RCFT) following a single tDCS session (2 mA, 20 minutes) relative to participants in a sham-tDCS group was tested.Öğe A possible link between the mitochondrial gatekeeper pyruvate dehydrogenase enzyme complex and EMT(Science Direct, 2018) Cevatemre, B.; Dere, E.; Ulukaya, EnginIntroduction In recent years, mitochondria have attracted much attention in metastatic cancer research. The first finding of the importance of mitochondria in cancer was reported by Otto Warburg in 1920. In the following years,it was found that cancer is closely related to mitochondrial characteristics such as glucose metabolism and chemoresistance. In this context,epithelial mesenchymal transition (EMT), due to its potential of being a molecular marker for tumour metastasis, clarification of this process is essential. Although increments have been made in metastatic cancer research,there are no studies showing the relationship between pyruvate dehydrogenase enzyme complex (PDH) and EMT.Öğe Effectiveness of tDCS blinding protocol in a sham-controlled study(Science Direct, 2017) Dinn, W.; Göral, F.; Adıgüzel, S.; Karamürsel, Sacit; Fregni, F.; Ayçiçeği-Dinn, A.There are surprisingly few studies investigating the effectiveness of transcranial direct current stimulation (tDCS) blinding protocols. The objective of the present study was to determine whether a commonly used DC stimulator (neuroConn, Ilmenau, Germany) effectively blinds subjects participating in a single trial, double-blind/sham-controlled protocol. We investigated the question by analyzing blinding assessment in a double-blinded tDCS memory trial. Findings from that trial will be reported elsewhere (i.e., separate abstract submitted to the brain stimulation conference). Subjects were instructed to indicate whether they received 20 minutes of active- or sham-tDCS to determine whether blinding was successful. Participants were informed prior to the stimulation session that they would be assigned to an active- or sham-tDCS group. University students were assigned to genuine-tDCS (n = 27) or sham-tDCS (n = 26) groups. Subjects in the active-tDCS group underwent left DLPFC anodal/right frontopolar cathodal stimulation during a single tDCS session (2 mA, 20 minutes duration). During the sham session, genuine tDCS was delivered for the initial 30 seconds of the 20 minute session. The initial scalp sensations associated with tDCS (e.g., tingling) were experienced by participants receiving sham stimulation. Thus, the subject should be unaware of his/her group assignment. Analysis revealed that 29 of 53 subjects (54.7 %) correctly identified group assignment (binomial test, p = .58). 22 of 27 subjects (81.4 %) in the active-tDCS group correctly identified group assignment (i.e., believed that they had received genuine tDCS), while only 7 of 26 (26.9%) participants in the sham group correctly identified group assignment (i.e., stated that they had received “sham” stimulation). Thus, 19 of 26 participants (73.0 %) assigned to the sham group believed that they had received genuine tDCS. Results support the use of the current blinding protocol in single trial, sham-controlled tDCS studies.Öğe Effects of VEGF plus adipose tissue derived mesenchymal stem cells with platelet rich plasma on inbred rat ovarian functions in premature ovarian insufficiency model(Oxford Univ Press, 2017) Vural, B.; Duruksu, G.; Vural, F.; Görgüç, M.; Karaöz, ErdalWhat is known already: Numerous studies have found an increased risk of congenital malformations among live-born children conceived after assisted reproduction compared with spontaneously conceivedchildren. The underlying subfertility matters, as children born by couples taking a long time to conceive spontaneously also have an increased risk of congenital malformations. Still the assisted reproductive technology may also play a role. Little is known concerning the prenatal detection rate of fetal malformations in pregnancies conceived after assisted reproduction and it is unclear if women pregnant after assisted reproduction are more or less likely to terminate a pregnancy due to a fetal malformation.Öğe Control of actin nucleators by maturation regulating factors in mouse oocytes(Oxford Univ Press, 2018) Tepeköy Özçelik, Filiz; Akkoyunlu, G.: Does MAPK/ERK kinase (MEK) inhibition and maturation promoting factor (MPF) activation affect actin nucleators Spire-1 and Spire-2 in mouse oocytes?Öğe Dual inhibition of Wnt/beta-catenin signaling and histone deacetylation as a new strategy to eliminate breast cancer stem cells by augmentation of apoptosis(Wiley, 2018) Aztopal, Nazlıhan; Erkısa Genel, Merve; Arı, Ferda; Dere, E.; Ulukaya, Engin[No Abstract Available]Öğe Standardization of gut microbiota analysis: variability in samples taken at different times from single case and the effect of the freezing the sample(Elsevier Sci Ltd, 2018) Sağlam Yarımcan, FilizBackground: Gut microbiota analysis can help understand many diseases some of which, like in?ammatory bowel diseases, obesityanddiabetesarealreadyestablishedandtheothersaretobe determined.Usingthistestfordiagnosticpurposesandestablishing personalizedcareseemstobecomearoutineprocedurethatneeds standardizationprotocols.Theaimofthisstudywastoanalyzethe changesingutmicrobiotacommunitiesinsamplestakenfromsingle case at different times and the effect of storing the samples in -20?C before processing them. Methods&Materials:Ontheday1andtheday8,twostoolsamples were obtained from a single case, 40-year-old woman using insulin for the control of her Type 1 Diabetes Mellitus. The ?rst sample were processed in 2hours and part of it was kept in -20 until day 8. The second stool sample was processed together with the frozen sample in 2hours. DNA was obtained with fecal DNA extraction kit (QIAGENE). The microbiota was determined using Ion16SrRNAMetagenomicKitonIonTorrentplatform.Theextractionweredoneasmentionedaboveandmetagenomicstudieswere doneforallsamplesinasinglerunandchip.Thecomparisonofthe results was done using t-test with SPSS (IBM) software. Results: Six phyla were determined: Bacteriodetes, Firmicutes, Proteobacteria, Tenericutes, Actinobacteria and Verrucomicrobia. Bacteriodetes and Firmicutes formed the majority of the bacterial population studied. Bacteriodetes were 57% in the 1st day fresh sample and 28% in the frozen one. Bacteriodetes ratio in 8th day sample was 44%. Firmicutes formed 35% in 1st day fresh sample, 38%and19%infrozenand8thdaysamplesrespectively.Proteobacteria ratios were high in frozen and 8th day samples: 31% and 36%. Proteobacteria formed 7% of bacterial population in the 1st dayfreshsample.Tenericutes,ActinobacteriaandVerrucomicrobia were below 1% in all samples.Öğe Comprehensive analysis of transcriptomic portrait of T-cell acute lymphoblastic leukemia by RNA sequencing(Pergamon-Elsevier Science Ltd, 2018) Sun, Eda; Ng, O. Hatırnaz; Erbilgin, Y.; Fırtına, S.; Sayitoğlu, M.Objective: T cell-acute lymphoblastic leukemia (T-ALL) is one of the most aggressive treatment-resistant types of leukemia, which has no specific prognostic marker for disease follow up. Objective: The aim of this study is to demonstrate the altered genes in T-ALL, WNT-specific analysis of exhibit abnormal activity in the T-ALL and identify the tissue-specific expressions of alternative splicing products by transcriptome sequencingÖğe Measurement and evaluation of human functions(Wiley, 2018) Kurdak, Sadi; Yazıhan, Nuray; Ermutlu, Numan; Kutlu, Selim; Ayar, Ahmet; Kozanoğlu, İlknurIn general, health status can be defined as normal (physiological) function of the system and organs in the human body. The objective measurement of the human body and its functions is the subject of medicine mainly physiology.Öğe Case report of a young patient with transthyretin amyloidosis associated with Gly67Ala mutation(Taylor & Francis Ltd, 2019)Hereditary transthyretin-mediated amyloidosis (hATTR) is a rare, systemic and progressive autosomal dominant disease caused by mutations in the TTR gene. Systemic deposition of amyloidogenic mutant transthyretin results in organ dysfunction [1]. While the Val30Met has been considered to be the most common mutation there have been more than 120 amyloidogenic TTR mutations reported worldwide [2]. Phenotypic expression of hATTR is heterogeneous and influenced by TTR genotype, geographic location and other genetic and environmental factors [3]. The heterogeneity of this rare disease makes its diagnosis challenging.Öğe Identification of microenvironmental regulation and therapeutic targeting of oncogenic eEF2K in pancreatic cancer(Wiley, 2019) Karakaş Zeybek, Didem; Kahraman, Nermin; Bayraktar, Recep; Kabil, Nashwa; Ulukaya, Engin; Dere, Egemen; Berestein, Gabriel Lopez; Özpolat, BülentEukaryotic elongation factor 2 kinase (eEF2K) is overexpressed in cancer cells and its overexpression is correlated with poor prognosis in several types of cancer. It has been known that pancreatic cancer (PaCa) has a unique tumor microenvironment (TME) which contributes all stages of tumorigenesis. In this study, the effects of interaction between PaCa cells and macrophages on eEF2K levels and aggressive tumor behaviours were investigated.Öğe The clinical significance of jak2v617f mutation for philadelphia-negative chronic myeloproliferative neoplasms in patients with splanchic vein thrombosis(Cig Media Group, Lp, 2019) Hindilerden, Fehmi; Hindilerden, İpek Yonal; Pınarbaşı Şimşek, Binnur; Hançer, Veysel Sabri; Kaymakoğlu, Sabahattin; Küçükkaya, Reyhan Diz; Nalçacı, MelihaContext: High prevalence of JAK2V617F mutation in splanchic vein thrombosis (SVT), including Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT) raised suspicion of an underlying Philadelphiaenegative chronic myeloproliferative disease (MPD).Öğe The investigation of plasma viscosity and endothelial dysfunction markers between patients diagnosed with essential thrombocytosis and reactive thrombocytosis(Pergamon-Elsevier Science Ltd, 2019) Karış, Denizhan; Tekin, Tuba Özkan; Çetin, Güven; Ercan, Alev MeltemEssential thrombocytosis (ET) is a rare stem cell disease causing increased platelet numbers with impaired function. Biomechanical force applied by plasma viscosity-a major determinant of blood flow-alterations on endothelium, induces endothelial cells for secretion of endothelial dysfunction markers. The aim of our study is to investigate the relationship between plasma viscosity and nitric oxide (NO), asymmetric dimethylarginine (ADMA), vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) as endothelial dysfunction markers in plasma.Öğe Effects of novel targeted anticancer drugs on cytotoxicity, apoptosis, angiogenesis, EMT, drug resistance and autophagic mechanism(Oxford Univ Press, 2019) Aydınlık, S.; Üvez, A.; Armutak, E. I.; Dere, E.; Ulukaya, EnginBackground: Metastatic coloncancer has asurvival rate less than %5 despite the use of effective chemotherapeutic regimen. Prognosticand predictiveimportance of EGFR is still contradictivein coloncancer. Tyrosine kinase inhibitor canertinib was used in this study toblock the EGFR receptor. Theeffectof Palladium (Pd) (II)compound [PdCl(terpy)](sac).2H2O]andcanertinib combination treatment was investigated in this study. 5-fluorouracil(5-FU),a chemotherapeutic drug was used aspositive control.Öğe The effect of NOTCH, IL-1 and LEPTIN (NILCO) inhibition in xenograft colorectal cancer(Wiley, 2019) Özyurt, R.; Erkasap, N.; Özkurt, M.; Erkasap, S.; Ulukaya, Engin; Dimas, K.Questions: Studies in various cancer tissues have shown that Notch, IL-1 and leptin interaction (NILCO) play a role in the proliferation, migration and expression of proangogenic molecules. It has been suggested that VEGF/VEGFR2 gene expression in angiogenesis may increase by NILCO and may contribute significantly to tumor development. However, there is no any comprehensive molecular study of the relationship between NILCO pathway and cancer development in colon tissue. For this purpose, we studied the effect of NILCO and related angiogenic/proinflammatory molecules on xenograft colorectal cancer (CRC).
