Effect of pirfenidone on tendon healing

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dc.authoridKaya, Burak/0000-0001-8516-3658
dc.authoridEYİDOGAN, ABDULLAH/0000-0003-1656-9990
dc.authorwosidKaya, Burak/AAM-7530-2020
dc.authorwosidEYİDOGAN, ABDULLAH/AAF-9911-2020
dc.contributor.authorAydinli, Yasemin
dc.contributor.authorKaya, Burak
dc.contributor.authorAbou Monsef, Yanad
dc.contributor.authorEyidogan, Abdullah
dc.date.accessioned2024-05-19T14:38:52Z
dc.date.available2024-05-19T14:38:52Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: The most critical issues in tendon healing include tendon adhesions and a loss of tendon strength. Adhesions result from fibrotic tissues developing in both surrounding tissues and tendons. Materials and Methods: Twenty-four rats were divided into two groups. Their Achilles tendons were cut 4 mm proximal to the calcaneal insertion and sutured with 6 / 0 monofilament nonabsorbable sutures. In the control group, saline solution was applied to the surgical field. In the experimental group, pirfenidone was applied to the surgical field locally and given orally for each rat to provide both local and systemic effects for 14 days following surgery. After a gait analysis, rats were sacrificed during the 4th postoperative week, and macroscopical, histopathological, and biomechanical analyses were performed. Results were compared with the statistical analyses. Results: The macroscopic scores of the experimental group were significantly higher than the control group (P = 0.007). The Achilles functional index scores were not significantly different between the two groups (P = 0.55). Histopathological scores were substantially closer to healthy tendons in the experimental group (P = 0.004). Biomechanically, the force required to rupture the tendons and tendon stiffness was significantly greater in the experimental group than in the control group (P = 0.028 for both). Conclusion: This study shows that tendons healed better with pirfenidone treatment.en_US
dc.identifier.doi10.4103/tjps.tjps_24_23
dc.identifier.endpage129en_US
dc.identifier.issn1300-6878
dc.identifier.issn2528-8644
dc.identifier.issue4en_US
dc.identifier.startpage123en_US
dc.identifier.urihttps://doi.org10.4103/tjps.tjps_24_23
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4634
dc.identifier.volume31en_US
dc.identifier.wosWOS:001082913500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofTurkish Journal of Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAdhesionen_US
dc.subjectAntifibrotic Agentsen_US
dc.subjectPirfenidoneen_US
dc.subjectRaten_US
dc.subjectTendon Healingen_US
dc.titleEffect of pirfenidone on tendon healingen_US
dc.typeArticleen_US

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