Functional recovery after wharton’s jelly–derived mesenchymal stem cell administration in a patient with traumatic spinal cord injury: a pilot study

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dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorwosidErdal Karaöz / IXE-6677-2023
dc.contributor.authorKabataş, Serdar
dc.contributor.authorCivelek, Erdinç
dc.contributor.authorSavrunlu, Eyüp Can
dc.contributor.authorKaplan, Necati
dc.contributor.authorÇetin, Ercan
dc.contributor.authorDiren, Furkan
dc.contributor.authorBoyali, Osman
dc.contributor.authorGüven, Göksel
dc.contributor.authorKaraöz, Erdal
dc.date.accessioned2021-07-08T12:12:10Z
dc.date.available2021-07-08T12:12:10Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe use of stem cells in the treatment of traumatic spinal cord injury (SCI) in recent years has provided promising results. Different sources of cells for transplantation have been used, including mesenchymal stem cells [MSCs; e.g., Wharton’s jelly-derived (MSCs WJ-MSCs)]. Here, we reported on a 29-year-old man who was treated with WJ-MSCs in the course of therapy for blunt, traumatic SCI due to a work accident. He was operated on within 6 hours of the injury. Three and a half months later, he underwent intrathecal, intramuscular, and intravenous administrations of WJ-MSCs at a target dose of 1x106/kg for each application route (twice a month for 2 months). All the procedures were tolerated well by the patient. In parallel to this, we have not seen any application-related complications so far. After stem cell infusions, progressive improvements were shown in the patient’s neurological examination and neurophysiological and neuroradiological findings.en_US
dc.identifier.citationKABATAŞ S,KABATAŞ S,SAVRUNLU E. C,KAPLAN N,CETIN E,DİREN F,BOYALI O,GÜVEN G,KARAÖZ E (2021). FUNCTIONAL RECOVERY AFTER WHARTON’S JELLY–DERIVED MESENCHYMAL STEM CELL ADMINISTRATION IN A PATIENT WITH TRAUMATIC SPINAL CORD INJURY: A PILOT STUDY. Journal of Turkish Spinal Surgery, 32(1), 38 - 46. Doi: 10.4274/jtss.galenos.2021.363en_US
dc.identifier.doi10.4274/jtss.galenos.2021.363en_US
dc.identifier.endpage46en_US
dc.identifier.issn2147-5903en_US
dc.identifier.issue1en_US
dc.identifier.startpage38en_US
dc.identifier.trdizinid430122en_US
dc.identifier.urihttps://doi.org/10.4274/jtss.galenos.2021.363
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1904
dc.identifier.volume32en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKaraöz, Erdal
dc.language.isoenen_US
dc.publisherGelenosen_US
dc.relation.ispartofJournal of Turkish Spinal Surgeryen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStem Cellen_US
dc.subjectTransplantationen_US
dc.subjectTraumatic Spinal Cord Injuryen_US
dc.subjectWharton’s Jellyen_US
dc.titleFunctional recovery after wharton’s jelly–derived mesenchymal stem cell administration in a patient with traumatic spinal cord injury: a pilot studyen_US
dc.typeArticleen_US

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