Effect of different latency periods on distraction osteogenesis in an experimental rabbit model Distraction osteogenesis and latent period

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dc.authoridÖzkan, Serbay/0000-0001-7854-4735
dc.authoridkilic, Mehmet/0000-0001-7013-7879
dc.authorwosidÖzkan, Serbay/D-6812-2019
dc.contributor.authorKilic, Mehmet
dc.contributor.authorYurteri, Ahmet
dc.contributor.authorSokucu, Sami
dc.contributor.authorCetin, Mehmet Umit
dc.contributor.authorOzkan, Serbay
dc.contributor.authorCetin, Engin
dc.contributor.authorSenturk, Gozde Erkanli
dc.date.accessioned2024-05-19T14:40:54Z
dc.date.available2024-05-19T14:40:54Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAim: This work used immunohistochemical and radiographic analysis to show how latency time affects distraction osteogenesis in animals. Material and Methods: Eighteen rabbits had right femur drill osteotomies and external fixators. Latency duration split the rabbits into three groups. Groups 1, 2, and 3 had latency times of 1, 5, and 10 days. After the latency period, all groups had a 20-day consolidation phase. After consolidation, the animals were euthanized, and immunohistochemical, histological, and radiological studies were performed on the distraction-induced callus tissue. Results: In radiological evaluation, there was no significant difference between Group 1 and Group 2 and Group 2 and Group 3 (p=1,000, p=0,066). Group 1 and 3 differed (p=0.018). Histopathological assessment showed no significant difference between Group 1 and Group 2 or Group 2 and Group 3 (p= 0,557, p=0,062). Group 1 and 3 differed (p=0,001). Group 3 had more osteocalcin-positive cells than Groups 1 and 2. Discussion: Histopathological and radiographic methods showed that a 10-day distraction osteogenesis latency time in rabbit femurs is safer than 1 and 5-day periods. Human distraction osteogenesis latency must be determined by clinical trials.en_US
dc.description.sponsorshipGaziosmanpasa Taksim Health Training and Educational Hospital, Scientific Research Project (BAP) Council [10]; National Institutes of Health Research (NIHR) [10] Funding Source: National Institutes of Health Research (NIHR)en_US
dc.description.sponsorshipGaziosmanpasa Taksim Health Training and Educational Hospital, Scientific Research Project (BAP) Council (Project approval number/date: 10/14.09.2017).en_US
dc.identifier.doi10.4328/ACAM.21887
dc.identifier.endpage253en_US
dc.identifier.issn2667-663X
dc.identifier.startpage248en_US
dc.identifier.urihttps://doi.org10.4328/ACAM.21887
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5034
dc.identifier.volume14en_US
dc.identifier.wosWOS:001087343700008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectDistraction Osteogenesisen_US
dc.subjectLatency Perioden_US
dc.subjectOsteotomyen_US
dc.subjectRabbit Modelen_US
dc.titleEffect of different latency periods on distraction osteogenesis in an experimental rabbit model Distraction osteogenesis and latent perioden_US
dc.typeArticleen_US

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