IL-10, IL-13, IL-17 and CXCL8, CXCL10: Their relationship with the development and prognosis of type 1 and type 2 diabetes

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dc.authoridPehlivanoğlu, Cemil/0000-0003-1466-5831
dc.authoridGürol, Ali Osman/0000-0001-6682-4289
dc.authoridÇakmak, Ramazan/0000-0003-3815-7444
dc.authorwosidPehlivanoğlu, Cemil/AGQ-5537-2022
dc.authorwosidTekin, Sakin/HJP-0599-2023
dc.authorwosidAydin Ozgur, Burcin/HJB-1746-2022
dc.authorwosidGürol, Ali Osman/AAE-2984-2020
dc.authorwosidÇakmak, Ramazan/AAG-4665-2019
dc.contributor.authorEbrahimzadeh, Mina
dc.contributor.authorPehlivanoglu, Cemil
dc.contributor.authorOzgur, Burcin Aydin
dc.contributor.authorKucuksezer, Umut Can
dc.contributor.authorDegirmencioglu, Sevgin
dc.contributor.authorTekin, Sakin
dc.contributor.authorCakmak, Ramazan
dc.date.accessioned2024-05-19T14:40:37Z
dc.date.available2024-05-19T14:40:37Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAim: Diabetes mellitus (DM) is a chronic high blood sugar disorder that can be classified into two groups: type 1 diabetes (T1D) and type 2 diabetes (T2D). The equilibrium between cytokines and chemokines is important for the development and prognosis of the disease. This study aimed to examine the contribution of pro-inflammatory (IL-17, CXCL8, CXCL10) and anti-inflammatory (IL-10, IL-13) factors to the development and prognosis of T1D and T2D. Material and Methods: Cytokine and chemokine levels were evaluated in serum samples of patients with T1D and T2D, and healthy controls. Patients were divided into two groups depending on the history of the disease, as 1-5 years and 5-10 years. HbA1C levels were assessed by HPLC. Concentrations of IL-17, CXCL-8, CXCL-10 and IL-10, IL-13 were analyzed using LUMINEX.Results: A statistically significant difference was observed in the HbA1c levels of all patients versus controls. CXCL8 was increased in patients with T1D compared with the controls. There was a significant difference in IL-13 levels between patients with T1D or T2D over five years and controls. For IL-10 and CXCL-10, there was a significant difference between T1D for more than 5 years and T1D for 5 years or less.Discussion: Cytokines and chemokines are belonging to the immune system, but it is now known that they may also affect non-immune mechanisms. As a result, it is advantageous to take these factors almost equally into account in the diagnosis and treatment of T1D and T2D.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University [TYL-2017-23598]en_US
dc.description.sponsorshipThis study was funded by the Scientific Research Projects Coordination Unit of Istanbul University. Project number: TYL-2017-23598en_US
dc.identifier.doi10.4328/ACAM.21655
dc.identifier.endpage545en_US
dc.identifier.issn2667-663X
dc.identifier.issue6en_US
dc.identifier.startpage541en_US
dc.identifier.urihttps://doi.org10.4328/ACAM.21655
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4990
dc.identifier.volume14en_US
dc.identifier.wosWOS:001019537100014en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCytokinesen_US
dc.subjectChemokinesen_US
dc.subjectDiabetesen_US
dc.titleIL-10, IL-13, IL-17 and CXCL8, CXCL10: Their relationship with the development and prognosis of type 1 and type 2 diabetesen_US
dc.typeArticleen_US

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