Elevated blood basophil count may has a role in etiopathogenesis of isolated coronary artery ectasia

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dc.authoridHidayet Kayançiçek / 0000-0001-6493-5591
dc.authorscopusidHidayet Kayançiçek / 15837302900
dc.authorwosidHidayet Kayançiçek / DUY-5949-2022
dc.contributor.authorYılmaz, Mucahit
dc.contributor.authorKayançiçek, Hidayet
dc.contributor.authorGözel, Nevzat
dc.contributor.authorÇekici, Yusuf
dc.contributor.authorBilen, Mehmet Nail
dc.contributor.authorSarıoğlu, Güney
dc.contributor.authorKeleş, Fikret
dc.contributor.authorKorkmaz, Hasan H.
dc.date.accessioned2020-11-23T12:50:43Z
dc.date.available2020-11-23T12:50:43Z
dc.date.issued2019en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe pathophysiology of isolated coronary artery ectasia (CAE) takes in inflammation and atherosclerosis. It is clear that basophils have a critical role in endothelial dysfunction, atherosclerosis and inflammation. In this study, it was aimed to examine the association between isolated CAE and basophilia. All cases who underwent coronary angiography between January 2013 and April 2018 evaluated retrospectively. Of 10985 cases, 173 (107 males) with isolated CAE and 220 with normal coronary angiography (NCA) that age and gender matched subjects (119 males) were recorded. Hospital’s database was used to derive the biochemical and hematological test results, and baseline characteristics. White blood cell (WBC) count and basophil count were significantly elevated for the cases that have angiographic isolated CAE when compared to the subjects with NCA [ 7.87 (6.83-9.42)109 / L vs 7.48 (6.27-8.67) 109 / L, p=0.01; 0.04 (0.03-0.05) 109 / L vs 0.03 (0.02-0.05) 109 / L, p=0.03, respectively]. According to receiver operating characteristics curve analyses (ROC); the specificity of a basophil value>0.037 109 / L (measured prior to coronary angiography) in predicting isolated CAE was 57,3% and the sensitivity was 57.2% (area under the curve [AUC] 0.562, 95% CI 0.505, 0.618; p=0.03). Patients with isolated CAE have higher blood basophil count. Elevated blood basophil count may have a substantial mission in the pathogenesis of isolated CAE.en_US
dc.identifier.citationYİLMAZ M,KAYANCİCEK H,GOZEL N,CEKİCİ Y,BİLEN M. N,SARİOGLU G,KELES F,KORKMAZ H. H (2019). Elevated blood basophil count may has a role in etiopathogenesis of isolated coronary artery ectasia. Medicine Science, 8(4), 800 - 806. Doi: doi: 10.5455/medscience.2019.08.9090en_US
dc.identifier.doi10.5455/medscience.2019.08.9090en_US
dc.identifier.endpage806en_US
dc.identifier.issn2147-0634en_US
dc.identifier.issn2147-0634en_US
dc.identifier.issue4en_US
dc.identifier.startpage800en_US
dc.identifier.trdizinid378921en_US
dc.identifier.urihttps://doi.org/10.5455/medscience.2019.08.9090
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1242
dc.identifier.volume8en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKayançiçek, Hidayet
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIsolated Coronary Artery Ectasiaen_US
dc.subjectBlood Basophil Levelsen_US
dc.subjectInflammationen_US
dc.titleElevated blood basophil count may has a role in etiopathogenesis of isolated coronary artery ectasiaen_US
dc.typeArticleen_US

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