Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorEntezari, Maliheh
dc.contributor.authorGhanbarirad, Maryam
dc.contributor.authorTaheriazam, Afshin
dc.contributor.authorSadrkhanloo, Mehrdokht
dc.contributor.authorZabolian, Amirhossein
dc.contributor.authorGoharrizi, Mohammad Ali Shekhi Beig
dc.contributor.authorHushmandi, Kiavash
dc.contributor.authorAref, Amir Reza
dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorZarrabi, Ali
dc.contributor.authorNabavi, Noushin
dc.contributor.authorRabiee, Navid
dc.contributor.authorHashemi, Mehrdad
dc.contributor.authorSamarghandian, Saeed
dc.date.accessioned2022-09-22T07:39:54Z
dc.date.available2022-09-22T07:39:54Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractAmong the different kinds of tumors threatening human life, lung cancer is one that is commonly observed in both males and females. The aggressive behavior of lung cancer and interactions occurring in tumor microenvironment enhances the malignancy of this tumor. The lung tumor cells have demonstrated capacity in developing chemo- and radio-resistance. LncRNAs are a category of non-coding RNAs that do not encode proteins, but their aberrant expression is responsible for tumor development, especially lung cancer. In the present review, we focus on both lncRNAs and exosomal lncRNAs in lung cancer, and their ability in regulating proliferation and metastasis. Cell cycle progression and molecular mechanisms related to lung cancer metastasis such as EMT and MMPs are regulated by lncRNAs. LncRNAs interact with miRNAs, STAT, Wnt, EZH2, PTEN and PI3K/Akt signaling pathways to affect progression of lung cancer cells. LncRNAs demonstrate both tumor-suppressor and tumor-promoting functions in lung cancer. They can be considered as biomarkers in lung cancer and especially exosomal lncRNAs present in body fluids are potential tools for minimally invasive diagnosis. Furthermore, we discuss regulation of lncRNAs by anti-cancer drugs and genetic tools as well as the role of these factors in therapy response of lung cancer cells.en_US
dc.identifier.citationEntezari, Maliheh; Ghanbarirad, Maryam; Taheriazam, Afshin; Sadrkhanloo, Mehrdokht; Zabolian, Amirhossein; Goharrizi, Mohammad Ali Shekhi Beig; Hushmandi, Kiavash; Aref, Amir Reza; Ashrafizadeh, Milad; Zarrabi, Ali; Nabavi, Noushin; Samarghandian, Saeed; Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling; Biomedicine & Pharmacotheraphy(Volume 150, June 2022, 112963); DOI: 10.1016/j.biopha.2022.112963en_US
dc.identifier.doi10.1016/j.biopha.2022.112963en_US
dc.identifier.issn0753-3322en_US
dc.identifier.issue150en_US
dc.identifier.urihttp://doi.org/10.1016/j.biopha.2022.112963
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3179
dc.identifier.wosWOS:000852987900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBiomedicine & Pharmacotheraphyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLung Canceren_US
dc.subjectRadioresistanceen_US
dc.subjectLncRNAen_US
dc.subjectMiRNAen_US
dc.subjectChemoresistanceen_US
dc.titleLong non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodelingen_US
dc.typeArticleen_US

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