Beta 2 glycoprotein ı valine247leucine polymorphism in patients with antiphospholipid syndrome

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dc.authoridSenem Tekeoğlu / 0000-0001-5539-8755en_US
dc.authoridVeysel Sabri Hançer / 0000-0003-2994-1077
dc.authorscopusidVeysel Sabri Hançer / 6506533543
dc.authorwosidVeysel Sabri Hançer/ IZF-2126-2023
dc.contributor.authorTekeoğlu, Senem
dc.contributor.authorHançer,Veysel Sabri
dc.contributor.authorEsen, Bahar Artım
dc.contributor.authorNalçacı, Meliha
dc.contributor.authorİnanç, Murat
dc.contributor.authorKüçükkaya, Reyhan Diz
dc.date.accessioned2022-12-02T12:14:46Z
dc.date.available2022-12-02T12:14:46Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstract"Aim: Beta 2 Glycoprotein I (?2-GP I) takes part in the pathogenesis of antiphospholipid syndrome (APS). Valine247Leucine (Val247Leu) gene polymorphism of ?2-GP I might affect the binding/production of anti?2-GP I antibodies. Multiple studies are showing different frequencies of this polymorphism in various ethnic backgrounds; we aimed to determine the frequency and clinical importance of Val247Leu gene polymorphism of ?2-GP I in patients with APS and healthy. Methods: Eighty-three patients with APS [68 primary APS, 15 APS with systemic lupus erythematosus (SLE)] and 63 healthy individuals were included. ?2-GP I Val247Leu polymorphism was determined by quantitative real time polymerase chain reaction and melting curve analysis. The presence of anti-?2-GP I antibodies was detected by ELISA in the patient group. Results: Allele and genotype frequencies were similar between patients and healthy controls (p=0,307). V allele and VV genotype frequencies were significantly higher in primary APS patients with thrombocytopenia (p=0.040). There was no significant difference between ?2-GP I Val247Leu gene polymorphism and the anti?2-GP IgM and IgG antibody levels in the patient group (p=0.631 and p=0.077, respectively) Conclusion: This is the first study investigating the ?2-GP I Val247Leu gene polymorphism in the Turkish population. The frequencies of Val247Leu gene polymorphism of ?2-GP I were not different between patients with APS and healthy individuals in line with the other studies in Caucasian populations. Significantly high levels of V allele and VV genotype frequencies in primary APS patients could offer further insight to into the pathogenesis of thrombocytopenia in APS."en_US
dc.identifier.citationTekeoglu, S., Hancer, V. S., Artim-Esen, B., Nalcaci, M., Inanc, M., & Diz-Kucukkaya, R. (2022). Beta 2 glycoprotein I Valine247Leucine polymorphism in patients with antiphospholipid syndrome. Experimental Biomedical Research, 5(3), 293-302.en_US
dc.identifier.doi10.30714/j-ebr.2022.147en_US
dc.identifier.endpage302en_US
dc.identifier.issn2618-6454en_US
dc.identifier.issue3en_US
dc.identifier.startpage293en_US
dc.identifier.trdizinid530878en_US
dc.identifier.urihttp://dx.doi.org/10.30714/j-ebr.2022.147
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3414
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorTekeoğlu, Senem
dc.language.isoenen_US
dc.relation.ispartofExperimental Biomedical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntiphospholipid Syndromeen_US
dc.subjectBeta 2 Glycoprotein Ien_US
dc.subjectGene Polymorphismen_US
dc.subjectThrombocytopeniaen_US
dc.titleBeta 2 glycoprotein ı valine247leucine polymorphism in patients with antiphospholipid syndromeen_US
dc.typeArticleen_US

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