The novel translocation of t (1;21) in multiple myeloma with poor prognosis
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
DergiPark
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Multiple myeloma (MM) is characterized as the neoplastic proliferation of plasma cells producing a monoclonal paraprotein. The aim of this paper is to report complex karyotype that leads to a fatal clinical course in a patient with MM. Case: A 48-year-old male patient was diagnosed as MM free lambda. The karyotype of the patient was 46, XY, t(1;21) (p11;p11), del(3) (q25;q29), del(6) (q24;q26), t(11;14) (q13;q32), del(13) (q14;q21) in cytogenetic evaluation. Vincristine, doxorubicin and dexamethasone were started. The creatinine levels increased after the second course of chemotherapy, the chemotherapy protocol was switched to bortezomib and dexamethasone. Patient was admitted to the emergency department with pneumonia after the second chemotherapy cycle. Despite using broad spectrum antibiotics and oxygen support, he died after the development of sepsis syndrome. Conclusion: The anomaly of t (1;21) (p11;p11), that we detected in this case was detected in a case with MM for the first time and this anomaly has not been detected between these breaking points in any malignancies before. Although the prognostic impact of this unique anomaly may be unclear, further studies are needed to evaluate the effect of cytogenetic anomalies on prognosis of multiple myeloma.
Açıklama
Anahtar Kelimeler
Multiple Myeloma, Karyotyping, Chromosome Aberrations
Kaynak
Medical Science and Discovery
WoS Q Değeri
Scopus Q Değeri
Cilt
6
Sayı
4
Künye
Okay, M , Bozkurt, S , Özgeyik, M , Haznedaroğlu, İ . (2019). The novel translocation of t (1;21) in multiple myeloma with poor prognosis . Medical Science and Discovery , 6 (4) , 73-75 . DOI: 10.17546/msd.525213
