The novel translocation of t (1;21) in multiple myeloma with poor prognosis

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dc.authoridSüreyya Bozkurt / 0000-0002-1765-9894en_US
dc.authorscopusidSüreyya Bozkurt / 55540860700
dc.authorwosidSüreyya Bozkurt / AAP-1146-2020
dc.contributor.authorOkay, Mufide
dc.contributor.authorBozkurt, Süreyya
dc.contributor.authorÖzgeyik, Mehmet
dc.contributor.authorHaznedaroğlu, İbrahim Celalettin
dc.date.accessioned2021-06-23T06:29:19Z
dc.date.available2021-06-23T06:29:19Z
dc.date.issued2019en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Multiple myeloma (MM) is characterized as the neoplastic proliferation of plasma cells producing a monoclonal paraprotein. The aim of this paper is to report complex karyotype that leads to a fatal clinical course in a patient with MM. Case: A 48-year-old male patient was diagnosed as MM free lambda. The karyotype of the patient was 46, XY, t(1;21) (p11;p11), del(3) (q25;q29), del(6) (q24;q26), t(11;14) (q13;q32), del(13) (q14;q21) in cytogenetic evaluation. Vincristine, doxorubicin and dexamethasone were started. The creatinine levels increased after the second course of chemotherapy, the chemotherapy protocol was switched to bortezomib and dexamethasone. Patient was admitted to the emergency department with pneumonia after the second chemotherapy cycle. Despite using broad spectrum antibiotics and oxygen support, he died after the development of sepsis syndrome. Conclusion: The anomaly of t (1;21) (p11;p11), that we detected in this case was detected in a case with MM for the first time and this anomaly has not been detected between these breaking points in any malignancies before. Although the prognostic impact of this unique anomaly may be unclear, further studies are needed to evaluate the effect of cytogenetic anomalies on prognosis of multiple myeloma.en_US
dc.identifier.citationOkay, M , Bozkurt, S , Özgeyik, M , Haznedaroğlu, İ . (2019). The novel translocation of t (1;21) in multiple myeloma with poor prognosis . Medical Science and Discovery , 6 (4) , 73-75 . DOI: 10.17546/msd.525213en_US
dc.identifier.doi10.17546/msd.525213en_US
dc.identifier.endpage75en_US
dc.identifier.issn2148-6832en_US
dc.identifier.issue4en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.17546/msd.525213
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1816
dc.identifier.volume6en_US
dc.institutionauthorBozkurt, Süreyya
dc.language.isoenen_US
dc.publisherDergiParken_US
dc.relation.ispartofMedical Science and Discoveryen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMultiple Myelomaen_US
dc.subjectKaryotypingen_US
dc.subjectChromosome Aberrationsen_US
dc.titleThe novel translocation of t (1;21) in multiple myeloma with poor prognosisen_US
dc.typeArticleen_US

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