Anti-apoptotic effects of valproic acid treatment on dopaminergic neuronal loss in a 6-hydroxydopamine model of parkinson’s disease in rats

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dc.authoridSiğnem Eyüboğlu / 0000-0002-0253-2217en_US
dc.authorscopusidSiğnem Eyüboğlu / 57210738678
dc.authorwosidSiğnem Eyüboğlu / AAR-5224-2020
dc.contributor.authorCumbul, Alev
dc.contributor.authorGenç, Ece
dc.contributor.authorKeleş, Çiğdem Elif
dc.contributor.authorUslu, Ünal
dc.contributor.authorEyüboğlu, Siğnem
dc.date.accessioned2022-12-08T11:19:32Z
dc.date.available2022-12-08T11:19:32Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons resulting in deterioration of motor activity in patients. Currently, available therapies including Levodopa (L-DOPA) are more geared toward the treatment of symptoms. Therefore, developing effective neuroprotective therapies is needed. Valproic acid (VPA) has shown potent neuroprotective effects on dopamine (DA) neurons in various brain regions. The aim of this study is to investigate whether VPA attenuates the neuronal loss when co-treated with L-DOPA in a 6-hydroxydopamine (6-OHDA) induced PD model in rats. Methods: Male Wistar Albino rats received intranigral injection of 6-OHDA unilaterally. Twelve days later rats received either saline, L-DOPA, VPA, or L-DOPA+ VPA for 9 days. To determine whether rats had dopaminergic neuronal loss apomorphine-induced rotation test was used. Immunohistochemical analyses were performed in the Substantia Nigra pars compacta (SNpc) by measuring the tyrosine hydroxylase (TH) positive neurons and the apoptotic neurons. Results: 6-OHDA injection showed clinically impairment of the motor function with histologically significant damage to the dopaminergic neurons. VPA administration combined with L- DOPA protected neurons in SNpc by increasing the TH positive neurons and by decreasing the apoptotic neurons. L-DOPA given as a monotherapy, on the other hand, was ineffective on these parameters. Conclusion: Our experiments demonstrated that VPA had a neuroprotective effect when used with L-DOPA in the PD rat model.en_US
dc.identifier.citationCumbul, A., EYUBOGLU, S., KELEŞ, E. Ç., Unal, U. S. L. U., & Ece, G. E. N. Ç. Anti-apoptotic effects of valproic acid treatment on dopaminergic neuronal loss in a 6-hydroxydopamine model of Parkinson’s disease in rats. Anatolian Clinic the Journal of Medical Sciences, 27(2), 194-203.en_US
dc.identifier.doi10.21673/anadoluklin.1062913en_US
dc.identifier.endpage203en_US
dc.identifier.issn2149-5254en_US
dc.identifier.issn2458-8849en_US
dc.identifier.issue2en_US
dc.identifier.startpage194en_US
dc.identifier.trdizinid1109122en_US
dc.identifier.urihttp://dx.doi.org/10.21673/anadoluklin.1062913
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3447
dc.identifier.volume27en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorEyüboğlu, Siğnem
dc.language.isoenen_US
dc.relation.ispartofANADOLU KLİNİĞİ TIP BİLİMLERİ DERGİSİen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptozen_US
dc.subjectParkinson Hastalığıen_US
dc.subjectSıçan Modelien_US
dc.subjectTirozin Hidroksilazen_US
dc.subjectValproik Asiten_US
dc.subject6-Hidroksidopaminen_US
dc.titleAnti-apoptotic effects of valproic acid treatment on dopaminergic neuronal loss in a 6-hydroxydopamine model of parkinson’s disease in ratsen_US
dc.typeArticleen_US

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