The Relationship Between Carcinoembryonic Antigen and Epicardial Adipose Tissue

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dc.contributor.authorNaser, A.
dc.contributor.authorIsgandarov, K.
dc.contributor.authorGüvenç, T.S.
dc.contributor.authorDemir, İ.
dc.contributor.authorKirişci, M.
dc.contributor.authorEkmekçi, A.
dc.contributor.authorŞahin M.
dc.date.accessioned2024-05-19T14:33:33Z
dc.date.available2024-05-19T14:33:33Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: Inflammation, which is associated with an unhealthy lifestyle, plays a critical role in the development of both cardiometabolic diseases (CMD) and cancer. Carcinoembryonic antigen (CEA) is a tumor marker which also has proinflammatory properties. Recent studies have reported CEA to be associated with atherosclerosis, metabolic syndrome, and visceral adiposity. Epicardial adipose tissue (EAT) can exhibit highly inflammatory and pathogenic properties, and is a known risk factor for CMD. However, its relationship with CEA is still unknown. Objectives: This study aimed to investigate the possible association of CEA with EAT. Methods: A total of 134 Caucasian (males = 56, females = 78) individuals, aged (22-83 years), who were admitted for routine health control, were enrolled in this cross-sectional study. CEA was measured with chemiluminescent microparticle immunoassay (CMIA). EAT was measured by transthoracic echocardiography, and the visceral fat rating (VFR) was assessed by a body composition analyzing machine. The p-value <0.05 was considered statistically significant. Results: CEA levels were categorized as tertiles: T1, 0.5-1.04; T2, 1.06–1.69; and T3, ?1.7 ng/ml. The mean age, weight, VFR, EAT, and fasting glucose, as well as the median of systolic blood pressure (SBP), creatinine, and AST increased with the increasing CEA tertiles. CEA was significantly associated with EAT (r = 0.55, P<0.001) and VFR (r = 0.36, P<0.001). Multivariate linear regression analysis confirmed that gender, age, and EAT were the significant independent variables associated with CEA. Conclusion: Individuals with increased EAT have higher levels of CEA, suggesting that this biomarker is most likely produced by EAT; however, additional investigations are required to improve the present work. © 2023, Sociedade Brasileira de Cardiologia. All rights reserved.en_US
dc.identifier.doi10.36660/ijcs.20220222
dc.identifier.issn2359-4802
dc.identifier.scopus2-s2.0-85177180095en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.36660/ijcs.20220222
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4269
dc.identifier.volume36en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSociedade Brasileira de Cardiologiaen_US
dc.relation.ispartofInternational Journal of Cardiovascular Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCarcinoembryonic Antigenen_US
dc.subjectEpicardial Adipose Tissueen_US
dc.subjectInflammationen_US
dc.subjectPericardiumen_US
dc.titleThe Relationship Between Carcinoembryonic Antigen and Epicardial Adipose Tissueen_US
dc.typeArticleen_US

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