The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study

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dc.contributor.authorAksu, B.
dc.contributor.authorAfonso, A.C.
dc.contributor.authorAkil, I.
dc.contributor.authorAlpay, H.
dc.contributor.authorAtmis, B.
dc.contributor.authorAydog, O.
dc.contributor.authorBakkaloglu S.
dc.date.accessioned2024-05-19T14:33:32Z
dc.date.available2024-05-19T14:33:32Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: Congenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes. Methods: Among patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: uHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p < 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p < 0.0001), but was not different between the CAKUT subtypes (p > 0.05). Conclusion: Urine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage. Copyright © 2024 Aksu, Afonso, Akil, Alpay, Atmis, Aydog, Bakkaloglu, Bayazıt, Bayram, Bilge, Bulut, Cetinkaya, Comak, Demir, Dincel, Donmez, Durmus, Dursun, Dusunsel, Duzova, Ertan, Gedikbasi, Goknar, Guven, Hacihamdioglu, Jankauskiene, Kalyoncu, Kavukcu, Kenan, Kucuk, Kural, Litwin, Montini, Morello, Obrycki, Omer, Misirli Ozdemir, Ozkayin, Paripovic, Pehlivanoglu, Saygili, Schaefer, Schaefer, Sonmez, Tabel, Tas, Tasdemir, Teixeira, Tekcan, Topaloglu, Tulpar, Turkkan, Uysal, Uysalol, Vitkevic, Yavuz, Yel, Yildirim, Yildirim, Yildiz, Yuksel, Yurtseven and Yilmaz.en_US
dc.description.sponsorshipIstanbul Üniversitesi: 29652; Istanbul Üniversitesi; European Society for Paediatric Oncology, SIOPE: 5.2018; European Society for Paediatric Oncology, SIOPEen_US
dc.description.sponsorshipWe gratefully acknowledge that UTILISE was supported by Scientific Research Projects Coordination Unit of Istanbul University, by the European Society for Pediatric Nephrology (ESPN), by the Society for Children’s Kidney Health, and by Istanbul Faculty of Medicine Foundation. We are also very thankful to children participating in this study, our dedicated chemist Orhan Tepeli and diligent students of Istanbul University Istanbul Faculty of Medicine Zeynep Sakur, Sevgi Ipar, Isıl Gul for their great help and assistance.en_US
dc.description.sponsorshipThe author(s) declare financial support was received for the research, authorship, and/or publication of this article. UTILISE Study was supported by Scientific Research Projects Coordination Unit of Istanbul University (29652), by the European Society for Pediatric Nephrology (ESPN) (ESPN #5.2018), by the Society for Children’s Kidney Health (1.2018), and by Istanbul Faculty of Medicine Foundation. Acknowledgmentsen_US
dc.identifier.doi10.3389/fruro.2023.1281081
dc.identifier.issn2673-9828
dc.identifier.scopus2-s2.0-85187893854en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.3389/fruro.2023.1281081
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4266
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherFrontiers Media SAen_US
dc.relation.ispartofFrontiers in Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCakuten_US
dc.subjectChildrenen_US
dc.subjectCongenital Anomalies Of The Kidney And Urinary Tracten_US
dc.subjectHeat Shock Proteinsen_US
dc.subjectHsp70en_US
dc.subjectUtılıse Studyen_US
dc.titleThe relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE studyen_US
dc.typeArticleen_US

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