Growth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula in infants with cow’s milk protein allergy

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dc.contributor.authorKansu, A.
dc.contributor.authorUrganci, N.
dc.contributor.authorBukulmez, A.
dc.contributor.authorKutluk, G.
dc.contributor.authorGulcu, Taskin, D.
dc.contributor.authorSahin, Keskin, L.
dc.contributor.authorIgde M.
dc.date.accessioned2024-05-19T14:33:45Z
dc.date.available2024-05-19T14:33:45Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjective: To evaluate growth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula (eHCF) in infants with cow’s milk protein allergy (CMPA). Methods: A total of 226 infants (mean ± SD age: 106.5 ± 39.5 days, 52.7% were girls) with CMPA who received eHCF comprising at least half of the daily dietary intake were included. Data on anthropometrics [weight for age (WFA), length for age (LFA) and weight for length (WFL) z-scores] were recorded at baseline (visit 1), while data on infant feeding and stool records, anthropometrics and Infant Feeding and Stool Patterns and Formula Satisfaction Questionnaires were recorded at visit 2 (on Days 15 ± 5) and visit 3 (on Days 30 ± 5). Results: From baseline to visit 2 and visit 3, WFA z-scores (from ?0.60 ± 1.13 to ?0.54 ± 1.09 at visit 2, and to ?0.44 ± 1.05 at visit 3, p < 0.001) and WFL z-scores (from ?0.80 ± 1.30 to ?0.71 ± 1.22 at visit 2, and to ?0.64 ± 1.13 at visit 3, p = 0.002) were significantly increased. At least half of infants never experienced irritability or feeding refusal (55.7%) and spit-up after feeding (50.2%). The majority of mothers were satisfied with the study formula (93.2%), and wished to continue using it (92.2%). Conclusions: In conclusion, eHCF was well-accepted and tolerated by an intended use population of infants ? 6 months of age with CMPA and enabled adequate volume consumption and improved growth indices within 30 days of utilization alongside a favorable gastrointestinal tolerance and a high level of parental satisfaction. 2023 Kansu, Urganci, Bukulmez, Kutluk, Gulcu Taskin, Sahin Keskin, Igde, Molon, Dogan, Sekerel, Yuksek, Bostanci, Gerenli, Polat, Dalgic, Ayyildiz, Usta, Basturk, Yuce Kirmemis, Tuna Kirsaclioglu, Gulerman, Alptekin Sarioglu and Erdogan.en_US
dc.description.sponsorshipThis work was supported by Abbott Nutrition Turkey.en_US
dc.identifier.doi10.3389/fped.2023.1230905
dc.identifier.issn2296-2360
dc.identifier.scopus2-s2.0-85168164219en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fped.2023.1230905
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4326
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherFrontiers Media SAen_US
dc.relation.ispartofFrontiers in Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCow's Milk Protein Allergyen_US
dc.subjectExtensively Hydrolyzed Casein-Based Formulaen_US
dc.subjectGastrointestinal İntoleranceen_US
dc.subjectGrowth İndicesen_US
dc.subjectParental Satisfactionen_US
dc.subjectStool Patternsen_US
dc.titleGrowth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula in infants with cow’s milk protein allergyen_US
dc.typeArticleen_US

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