Preparation and evaluation of inflammation targeted nano-micellar formulation of celecoxib

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dc.authoridAyşe Şeyma Büyük / 0000-0001-8934-0359
dc.authorscopusidAyşe Şeyma Büyük / 57215857903
dc.authorwosidAyşe Şeyma Büyük / AAM-1484-2020
dc.contributor.authorBahadori, Fatemeh
dc.contributor.authorBüyük, Ayşe Şeyma
dc.contributor.authorKozanoğlu, Ahmed Serdar
dc.contributor.authorEskandari, Zahra
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorKepekçi Tekkeli, Şerife Evrim
dc.contributor.authorKoçyiğit, Abdurrahim
dc.date.accessioned2020-08-30T20:06:42Z
dc.date.available2020-08-30T20:06:42Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractObjective: Celecoxib (CLX), brand named Celebrex, which belongs to non-steroidal anti-inflammatory drugs family, selectively inhibits the cytokine related cyclooxygenase-2 isoenzyme and thus, possesses less gastrointestinal side effects, have shown to cause stroke, myocard infarction and even death in some cases. In this study we aimed to target inflammation site using CLX uploaded nano-micelles (nano-CLX) made of poly (lactic-co-glycolic) acid (PLGA) to protect other tissues from its side effects. Methods: CLX was physically entrapped in PLGA micelles using w/o/w emulsion method, resulted in obtaining mono-dispersed particles with 112 nm size. 50 mg PLGA was able to carry 50 mg CLX in 20 mL (2.5 mg/mL) with encapsulation efficiency of 85%. Rheumatoid arthritis model was achieved by injection of complete Freund's Adjuvant to the hint paw of Wistar rats. Infected groups received oral Celebrex, intravenous (i.v.) Celebrex and nano-CLX. Each group was compared with a healthy control group receiving the drug via the same routes. The obtained serums and the hint paw sizes were studied for 6 hours in 3 time periods. Results: Prostaglandin E2 and tumor necrosis factor-a levels were found to be decreased for longer time period by application of nano-CLX compared to oral and i.v. Celebrex. Interleukin-1 (IL-1) and IL-6 levels showed a dramatic decrease at orally administered Celebrex groups, showing the accumulation of these pro-inflammatory Factors at inflammation area. Conclusion: Based on the hypothesis that the ratio of blood parameters is inversely proportional to accumulation at inflammation site, thus, our nano-formulation is targeted to the tissues in the systemic blood flow and have a better selective inhibition.en_US
dc.identifier.citationBahadori, F., Buyuk, A. S., Kozanoglu, A. S., Eskandari, Z., Ankarali, H., Kepekci Tekkeli, S. E., & Kocyigit, A. (2019). Preparation and evaluation of inflammation targeted nano-micellar formulation of celecoxib.en_US
dc.identifier.doi10.14235/bas.galenos.2018.2673en_US
dc.identifier.endpage214en_US
dc.identifier.issn2148-2373en_US
dc.identifier.issue3en_US
dc.identifier.startpage208en_US
dc.identifier.urihttps://doi.org/10.14235/bas.galenos.2018.2673
dc.identifier.urihttps://hdl.handle.net/20.500.12713/597
dc.identifier.volume7en_US
dc.identifier.wosWOS:000499482100007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorBüyük, Ayşe Şeymaen_US
dc.language.isoenen_US
dc.publisherBezmialem Vakif Univen_US
dc.relation.ispartofBezmialem Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTargeted Inflammation Therapyen_US
dc.subjectCelecoxiben_US
dc.subjectNano Drug Delivery Systemen_US
dc.subjectPlgaen_US
dc.subjectCox2en_US
dc.titlePreparation and evaluation of inflammation targeted nano-micellar formulation of celecoxiben_US
dc.typeArticleen_US

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