The effect of Korean red ginseng on mesenchymal stem cells from healthy and osteoporotic human bone marrow

Basit Öğe Kaydı
dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authoridZehragül Ergül / 0000-0002-1466-5068
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorscopusidZehragül Ergül / 57204559825
dc.authorwosidErdal Karaöz / IXE-6677-2023
dc.authorwosidZehragül Ergül / EUM-6344-2022
dc.contributor.authorKepekci, Ahmet Hamdi
dc.contributor.authorErgül, Zehragül
dc.contributor.authorGultekin, Alper
dc.contributor.authorKaraöz, Erdal
dc.date.accessioned2020-09-25T08:56:20Z
dc.date.available2020-09-25T08:56:20Z
dc.date.issued2019en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: Osteoporosis is a disease characterized by an increase in bone fragility as a result of decreased bone mass and weakening of the bone structure. There are studies on the relationship between osteoporosis and hearing and balance system. The goal of this study was to compare the proliferation and osteogenesis induction properties of mesenchymal stem cells derived from healthy and osteoporotic individuals to better understand the healing properties of Korean red ginseng (KRG) and Panax ginseng-Avena Sativa-Tribulus Terrestris mixture (PAT). Materials and methods: Osteoporotic and healthy MSCs were isolated successfully in culture conditions. The proliferation levels of cells treated with different doses of KRG and PAT were compared by Water-Soluble Tetrazolium-1 (WST-1) assay. Alkaline phosphatase (ALP) assay was performed by selecting the most effective KRG dose in proliferation. Results: Morphology of isolated cells and the expression of cell surface antigens have been detected as similar. The WST-1 assay showed that KRG was effective on the proliferation of osteoporotic cells. The levels of ALP in osteoporotic cells treated with KRG is increased depending on the differentiation day compared to healthy cells. Conclusion: KRG triggered an increase in intracellular ALP levels of osteoporotic MSCs. It suggests that KRG on osteoporotic cells is influential in stimulating osteogenesis and may be useful in osteoporotic patients.en_US
dc.identifier.citationKepekci, A. H., Ergul, Z., Gultekin, A., & Karaoz, E. (2019). The effect of Korean red ginseng on mesenchymal stem cells from healthy and osteoporotic human bone marrow. International Journal of Physiology, Pathophysiology and Pharmacology, 11(3), 76.en_US
dc.identifier.endpage82en_US
dc.identifier.issn1944-8171en_US
dc.identifier.issue3en_US
dc.identifier.pmid31333810en_US
dc.identifier.startpage76en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1106
dc.identifier.volume11en_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErgül, Zehragül
dc.institutionauthorKaraöz, Erdal
dc.language.isoenen_US
dc.relation.ispartofInt J Physiol Pathophysiol Pharmacolen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKorean Red Ginsengen_US
dc.subjectMesenchymal Stem Cellsen_US
dc.subjectOsteoporotic Human Bone Marrowen_US
dc.titleThe effect of Korean red ginseng on mesenchymal stem cells from healthy and osteoporotic human bone marrowen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
1.pdf
Boyut:
1.05 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu