Identification of microenvironmental regulation and therapeutic targeting of ongenic EF-2 kinase in pancreatic cancer

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dc.authoridDidem Karakaş Zeybek / 0000-0002-3781-6834en_US
dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authorscopusidDidem Karakaş Zeybek / 56422040600
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorwosidDidem Karakaş Zeybek / L-6682-2018
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.contributor.authorKarakaş Zeybek, Didem
dc.contributor.authorKahraman, Nermin
dc.contributor.authorBayraktar, Recep
dc.contributor.authorKabil, Nashwa
dc.contributor.authorUlukaya, Engin
dc.contributor.authorDere, Egemen
dc.contributor.authorLopez-Berestein, Gabriel
dc.contributor.authorÖzpolat, Bülent
dc.date.accessioned2021-11-19T08:38:33Z
dc.date.available2021-11-19T08:38:33Z
dc.date.issued2018en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description.abstractIntroduction Pancreatic cancer (PaCa) is one of the most aggressive and deadliest cancer with 6 months average survival rate. Recent studies indicate that the tumour microenvironment (TME) plays an important role in all stages of tumorigenesis in PaCa. Therefore, both tumour cells and their TME should be targeted for an effective treatment. Eukaryotic elongation factor 2 kinase (EF2K) is an enzyme which is overexpressed in cancer cells and plays a key role in cancer cell survival under stress conditions. There is no study that have shown the relationship between EF2K and TME. Thus, we investigated that the effects of EF2K expression on PaCa cell line (PANC1) and the TME.en_US
dc.identifier.citationZeybek, D. K., Kahraman, N., Bayraktar, R., Kabil, N., Ulukaya, E., Dere, E., ... & Ozpolat, B. (2018). PO-289 Identification of microenvironmental regulation and therapeutic targeting of ongenic EF-2 kinase in pancreatic cancer. ESMO Open, 3, A340-A341.en_US
dc.identifier.doi10.1136/esmoopen-2018-EACR25.803en_US
dc.identifier.issn2059-7029en_US
dc.identifier.issueSupplement 2en_US
dc.identifier.urihttps://doi.org/10.1136/esmoopen-2018-EACR25.803
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2262
dc.identifier.volume3en_US
dc.institutionauthorKarakaş Zeybek, Didem
dc.institutionauthorUlukaya, Engin
dc.language.isoenen_US
dc.publisherScience Directen_US
dc.relation.ispartofESMO Openen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleIdentification of microenvironmental regulation and therapeutic targeting of ongenic EF-2 kinase in pancreatic canceren_US
dc.typeOtheren_US

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