How Similar are Molecular Characteristics of Mammary Paget’s Disease to Underlying Ductal Carcinoma? Discussion of 42 Cases from a Tertiary Care Hospital
Küçük Resim Yok
Tarih
2022
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Dergi ISSN
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Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: It is aimed to evaluate the expression of estrogen receptor (ER), progesterone receptor (PR), CerbB2 status, and molecular subtypes in mammary Paget disease and con- comitant ductal carcinoma and to discuss their concordance and their relation with other prognostic parameters. Methods: This retrospective study evaluated the clinical and morphological data of the mammary Paget disease and underlying ductal carcinoma; immunohistochemical estrogen/ PR and CerbB2 status; molecular subgroups and survival; and statistically compared all pa- rameters. Results: The study included 42 cases of mammary Paget’s disease (PD) and concomitant ductal carcinoma. In breast specimens, 15 cases (36%) had in situ, 4 (9.5%) invasive, and 23 (54%) in situ + invasive ductal carcinoma. Axillary nodal involvement was seen in 13 cases (31%) and all had invasive components. Respectively, ER and PR expressions were detected in 16 (38%) and 8 (19%) of the ductal carcinomas and in 10 (23.8%) and 6 (14.2%) of the cases with PD. CerbB2 expression was 93% (39 cases) in ductal carcinoma and 100% in PD with a 93% concordance. The most frequent molecular subtype was HER2-enriched subtype for both mammary ductal carcinoma (62%, 26 cases) and PD (76%, 32 cases) and the con- cordance was 82% (p=0.03). The survival was 46.00±32.64 months in the exitus group (n=8), all of which had invasive ductal components (p=0.03). Conclusion: ER and PR positivity were lower while CerbB2 was higher in Paget disease compared to concomitant ductal carcinoma. The most prominent molecular subtype was HER2-enriched subtype in both neoplasias. While hormonal and CerbB2 status of the tu- mors did not show any correlation with prognostic factors, existence of an invasive ductal component was the factor that correlated with survival.
Açıklama
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Kaynak
Southern Clinics of Istanbul Eurasia
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Scopus Q Değeri
Cilt
33
Sayı
4
