Venous leg symptoms, ecchymosis, and coldness in patients with peripheral varicose vein: A multicenter assessment and validation study (VEIN-VIOLET study)

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dc.contributor.authorYetkin, Ertan
dc.contributor.authorKutlu Karadag, Makbule
dc.contributor.authorIleri, Mehmet
dc.contributor.authorAtak, Ramazan
dc.contributor.authorErdil, Nevzat
dc.contributor.authorTekin, Gulacan
dc.contributor.authorOzyasar, Mehmet
dc.contributor.authorOzturk, Selcuk
dc.date.accessioned2021-03-31T07:45:25Z
dc.date.available2021-03-31T07:45:25Z
dc.date.issued2020en_US
dc.departmentÄ°stinye Ãœniversitesien_US
dc.descriptionYetkin, Ertan (corresponding author)en_US
dc.description.abstractObjectives We aimed to evaluate peripheral varicose vein symptoms including ecchymosis and coldness by using the Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms (VEINES-QoL/Sym) questionnaire. Methods A total of 1120 patients were enrolled to the analysis after the exclusion of 199 patients who did not match the inclusion criteria. Patients were asked to answer the VEINES-Sym questionnaire and questions about ecchymosis and coldness. Scores of ecchymosis and coldness were calculated similar to VEINES-Sym questionnaire. Classifications of peripheral varicose vein were made according to the clinical part of clinical, etiological, anatomical, and pathophysiological classification system and patients with grade 2 or higher were considered as positive for peripheral varicose vein. Results Frequency of symptoms present in the VEINES-Sym instrument, ecchymosis and coldness were significantly higher in patients with peripheral varicose vein. Mean score of each symptom was significantly lower in peripheral varicose vein patients including scores of ecchymosis and coldness. Logistic regression analysis revealed that presence of hemorrhoids and all symptoms in VEINES-Sym questionnaire except restless leg were significantly and independently associated with peripheral varicose vein. Besides, ecchymosis (odds ratio: 2.04, 95% confidence interval: 1.34-3.08, p = 0.008) but not coldness was significantly and independently associated with peripheral varicose vein. There was also significant correlation of VEINES-Sym score with ecchymosis (r = 0.43, p < 0.001) and coldness (r = 0.47, p < 0.001). Conclusions Venous leg symptoms present in VEINES-Sym questionnaire except restless legs, presence of hemorrhoids and ecchymosis are significantly and independently associated with peripheral varicose vein. Not only ecchymosis but also coldness has shown an independent association with total VEINES-Sym score.en_US
dc.identifier.citationYetkin, E., Kutlu Karadag, M., Ileri, M., Atak, R., Erdil, N., Tekin, G., ... & Ozturk, S. (2020). Venous leg symptoms, ecchymosis, and coldness in patients with peripheral varicose vein: A multicenter assessment and validation study (VEIN-VIOLET study). Vascular, 1708538120980207.en_US
dc.identifier.doi10.1177/1708538120980207en_US
dc.identifier.isbn1708-5381
dc.identifier.issn1708-539Xen_US
dc.identifier.urihttps://doi.org/10.1177/1708538120980207
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1644
dc.identifier.wosWOS:000627541800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.relation.ispartofVASCULARen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeripheral Varicose Veinen_US
dc.subjectSymptomsen_US
dc.subjectLeg Diseasesen_US
dc.subjectEcchymosisen_US
dc.titleVenous leg symptoms, ecchymosis, and coldness in patients with peripheral varicose vein: A multicenter assessment and validation study (VEIN-VIOLET study)en_US
dc.typeArticleen_US

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