Combined Haploidentical Hematopoetic Stem Cell Transplantation and Liver Transplantation in a Pediatric Patient

Basit Öğe Kaydı
dc.contributor.authorUygun, V.
dc.contributor.authorAliosmanoğlu, İ.
dc.contributor.authorDaloğlu, H.
dc.contributor.authorÖztürkmen, S.
dc.contributor.authorYalçın, K.
dc.contributor.authorKarasu, G.
dc.contributor.authorYeşilipek A.
dc.date.accessioned2024-05-19T14:34:06Z
dc.date.available2024-05-19T14:34:06Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractSolid organ transplantation from the same donor is an established procedure for end-stage organ failure that developed after a previous hematopoietic stem cell transplantation (HSCT); however, it is rarely done in patients transplanted with unmanipulated haplo-HSCT. There are no pediatric reports regarding the long-term performance of organ transplantation after haplo-HSCT with post-transplant cyclophosphamide (PTCY). A juvenile myelomonocytic leukemia patient, who underwent unmanipulated haplo-HSCT with PTCY from her mother at the age of 3 years, developed chronic liver graft versus host disease (GvHD) which was refractory to specific GvHD treatment. Liver transplantation (LT) from her mother (the donor of her haplo-HSCT) was decided as the next line of treatment. LT was performed on day 540 post-HSCT, and the donor's left lateral segment was appropriately removed and attached to the recipient. The symptoms of GvHD completely regressed in a month. The patient died on day 121 after LT, because of a possible hepato-pulmonary syndrome. Organ failure can develop after allo-HSCT secondary to GvHD and therefore performing HSCT from a haplo-donor may be superior to a matched unrelated donor in terms of subsequent organ transplantation for organ failure. © 2023 Tehran University of Medical Sciences.en_US
dc.identifier.endpage295en_US
dc.identifier.issn1735-1243
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85174586850en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage291en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4410
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTehran University of Medical Sciencesen_US
dc.relation.ispartofInternational Journal of Hematology-Oncology and Stem Cell Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectHematopoetic Stem Cell Transplantationen_US
dc.subjectLiver Transplantationen_US
dc.subjectPost-Transplant Cyclophosphamideen_US
dc.titleCombined Haploidentical Hematopoetic Stem Cell Transplantation and Liver Transplantation in a Pediatric Patienten_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu