Combinations of wharton Jelly derived exosomes and salicylic acid: A new hope for eradication of cutaneous leishmaniasis

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dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorwosidErdal Karaöz / IXE-6677-2023en_US
dc.contributor.authorKöken, Gülnaz Yıldırım
dc.contributor.authorAbamor, Emrah Şefik
dc.contributor.authorAllahverdiyev, Adil
dc.contributor.authorKaraöz, Erdal
dc.date.accessioned2022-06-02T11:18:29Z
dc.date.available2022-06-02T11:18:29Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of the current study is to obtain wharton jelly derived exosomes, prepare therapeutic formulations including combinations of isolated exosomes and salicylic acid, investigate their in vitro antileishmanial activities against L.major promastigotes and amastigotes in order to develop a new alternative approach for recovery of Cutaneous Leishmaniasis. Exosomes isolated from mesenchymal stem cells were characterized by flow cytomeric analysis, zeta-sizer measurements and SEM visualization techniques. Following to demonstration of exosome existence, non-toxic concentrations of exosomes and salicylic acid were determined on L929 and J774 cells. The combined doses of exosomes and salicylic acid were applied on L.major promastigote and amastigote-macrophage culture by evaluation of various biological parameters of parasites such as viability, metabolic activity and infectivity. Obtained results indicate that combinations including non-toxic concentrations of exosome and salicylic acid displayed brilliant antileishmanial performances against each form of Leishmania parasites and this effect was too much bigger than use of these agents alone. We observed that combination applications substantially inhibited the viability and metabolic activity values of parasites and completely prevent the infection of macrophages with Leishmania promastigotes. These results reveal that exosome and salicylic acid combinations possessed significant inhibitory efficacies on L.major parasites. We foreseen that they would be further used in eradication of Cutaneous Leishmaniasis with a high success.en_US
dc.identifier.citationKoken, G. Y., Abamor, E. S., Allahverdiyev, A., Karaoz, E. (2022). Combinations of wharton Jelly derived exosomes and salicylic acid: A new hope for eradication of cutaneous leishmaniasis. Fresenius Environmental Bulletin, 31(3A), 3241-3256.en_US
dc.identifier.endpage3256en_US
dc.identifier.issn1018-4619en_US
dc.identifier.issue3Aen_US
dc.identifier.startpage3241en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2789
dc.identifier.volume31en_US
dc.identifier.wosWOS:000781628000023en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorKaraöz, Erdal
dc.language.isoenen_US
dc.publisherPARLAR SCIENTIFIC PUBLICATIONSen_US
dc.relation.ispartofFRESENIUS ENVIRONMENTAL BULLETINen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeishmaniasisen_US
dc.subjectExtracellular Vesiclesen_US
dc.subjectExosomeen_US
dc.subjectMesenchymal Stem Cellen_US
dc.subjectWharton Jellyen_US
dc.subjectSalicylic Aciden_US
dc.titleCombinations of wharton Jelly derived exosomes and salicylic acid: A new hope for eradication of cutaneous leishmaniasisen_US
dc.typeArticleen_US

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