Biocompatible silver nanoparticles from apricot kernel skin: a green synthesis approach to antibacterial and antiangiogenic therapies

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dc.authorscopusidOmid Nejati / 58087746400
dc.authorscopusidGülşah Torkay / 57753937500
dc.authorscopusidRemzi Okan Akar / 57210603359
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorwosidOmid Nejati / HJY-8539-2023
dc.authorwosidGülşah Torkay / IUP-3797-2023
dc.authorwosidRemzi Okan Akar / AAF-4576-2019
dc.authorwosidEngin Ulukaya / KYY-4020-2024
dc.authorwosidAyça Bal Öztürk / M-4472-2018
dc.contributor.authorNejati, Omid
dc.contributor.authorTorkay, Gülşah
dc.contributor.authorGirgin, Ayça
dc.contributor.authorZaman, Buse Tuğba
dc.contributor.authorAkar, Remzi Okan
dc.contributor.authorGiray, Betül
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2025-06-03T12:23:53Z
dc.date.available2025-06-03T12:23:53Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Lisansüstü Eğitim Enstitüsü, Sağlık Bilimleri, Kök Hücre ve Doku Mühendisliği Programı
dc.description.abstractPlant-based AgNPs synthesis has recently gained popularity due to its cost-effectiveness, feasibility, and environmentally friendly nature. In this study, we utilized apricot kernel skin extract for the first time as both a green reducing agent for silver ions and a stabilizing agent for the resulting AgNPs solution. This solution exhibited remarkable stability and biological activity. The biosynthesized AgNPs were characterized using several spectroscopic approaches. Particle size and zeta potential were found to be 145.5 ± 62.02 nm and − 29.1 ± 5.68 mV, respectively. The dynamic light scattering findings revealed a low polydispersity index of 0.229, indicating that the monodispersity distribution in solution is mainly single-sized and uniform species. The TEM image indicated that the AgNPs were spherical. Even 3 months after synthesis, AgNPs were stable. The DPPH test demonstrated that AgNPs have moderate antioxidant activity. Furthermore, depending on the dose, it is found to have high antibacterial activity against different bacterial species. It was also discovered that AgNPs, which are highly biocompatible with red blood cells in terms of hemolysis activity assay, were more lethal to non-small cell metastatic lung cancer epithelial cells (H1299) than human lung bronchial epithelial cells (Beas2B) with an LC50 of 6.03 and 14.19 μg/mL, respectively, after 24 h treatment. At TGI concentration, AgNPs also significantly reduced H1299 cell migration. According to artificial intelligence analyses acquired from in ovo chorioallantoic membrane testing, AgNPs, which hold great potential for application in anticancer drug delivery systems, have been also found to reduce angiogenesis at low concentrations. © The Author(s), under exclusive licence to the Institute of Chemistry, Slovak Academy of Sciences 2024.
dc.identifier.citationNejati, O., Torkay, G., Girgin, A., Zaman, B. T., Akar, R. O., Giray, B., ... & Bal-Öztürk, A. (2025). Biocompatible silver nanoparticles from apricot kernel skin: a green synthesis approach to antibacterial and antiangiogenic therapies. Chemical Papers, 79(1), 447-462.
dc.identifier.doi10.1007/s11696-024-03793-9
dc.identifier.endpage462
dc.identifier.issn03666352
dc.identifier.issue1
dc.identifier.scopusqualityQ2
dc.identifier.startpage447
dc.identifier.urihttp://dx.doi.org/10.1007/s11696-024-03793-9
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7272
dc.identifier.volume79
dc.identifier.wosWOS:001352551600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorNejati, Omid
dc.institutionauthorTorkay, Gülşah
dc.institutionauthorAkar, Remzi Okan
dc.institutionauthorUlukaya, Engin
dc.institutionauthorBal Öztürk, Ayça
dc.institutionauthoridOmid Nejati / 0000-0003-4983-9280
dc.institutionauthoridGülşah Torkay / 0000-0002-6803-494X
dc.institutionauthoridRemzi Okan Akar / 0000-0001-8687-2034
dc.institutionauthoridEngin Ulukaya / 0000-0003-4875-5472
dc.institutionauthoridAyça Bal Öztürk / 0000-0002-6502-528X
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofChemical Papers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApricot Kernel Skin Extract
dc.subjectCAM Assay
dc.subjectGreen Synthesis
dc.subjectSilver Nanoparticles
dc.titleBiocompatible silver nanoparticles from apricot kernel skin: a green synthesis approach to antibacterial and antiangiogenic therapies
dc.typeArticle

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