The Association between Aminoglycoside Exposure and Ototoxicity in Children with Cystic Fibrosis

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dc.authorscopusidNesibe Karasu / 59402022500
dc.authorwosidNesibe Karasu / LSV-0365-2024
dc.contributor.authorYılmaz Yeğit, Cansu
dc.contributor.authorErgenekon, Pınar
dc.contributor.authorYanaz, Mürüvvet
dc.contributor.authorÖztürk Akar, Nezafet
dc.contributor.authorToktaş Yavuz, Fatma
dc.contributor.authorMolla Kafi, Hale
dc.contributor.authorÇollak, Abdülhamit
dc.contributor.authorBal, Nilüfer
dc.contributor.authorGedik Toker, Özge
dc.contributor.authorMeral, Özge
dc.contributor.authorAtaş, Ahmet
dc.contributor.authorÇetin Kara, Halide
dc.contributor.authorKarasu, Nesibe
dc.date.accessioned2025-04-18T10:09:14Z
dc.date.available2025-04-18T10:09:14Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, İSÜ Hastaneleri
dc.description.abstractIntroduction: Pulmonary exacerbations increase the requirement of aminoglycoside (AG) antibiotics in people with cystic fibrosis (pwCF). Several studies have shown that AGs have a cumulative effect on ototoxicity. We aimed to investigate the relationship between AG exposure and ototoxicity by using 3 different methods in patients with CF. Materials/Methods: The multicenter study included 121 pwCF aged between 5 and 18 years with a history of parenteral AG exposure. Standard pure-tone audiometry, extended high-frequency pure-tone audiometry (EHF-PTA), and distortion-product otoacoustic emissions (DPOAE) tests were performed. Mitochondrial mutation analysis for m1555G>A was performed in 61 patients. Results: Median age was 12.85 years and 52.1% (n = 63) were male. 18.2% (n = 22) of the patients had received parenteral AGs more than 5 courses/lifetime. Ototoxicity was detected in at least one of the tests in 56.2% (n = 68) of the patients. Only 10.7% (n = 13) of the patients had reported a symptom indicating ototoxicity. 30.3% (n = 30) of the patients had ototoxicity in the low exposure group, while it was 45.5% (n = 10) in the high exposure group according to EHF-PTA (p > 0.05). Median number of parenteral amikacin courses was significantly higher in the ototoxic group (2 [1.25-5.75] vs. 2 [1-3]; p = 0.045). No m1555A>G mutation was detected in 61 patients who screened for mitochondrial mutation analysis. Conclusion: As AG ototoxicity occurs primarily at high frequencies, EHF-PTA is important in early detecting ototoxicity. EHF-PTA and DPOAE detected ototoxicity in some patients with normal PTA results. All pwCF with a history of AG exposure should be evaluated for hearing loss since symptoms may only be noticed in the late period. © 2024 S. Karger AG, Basel.
dc.description.sponsorshipThis study was developed as an American Thoracic Society MECOR (Methods in Epidemiologic, Clinical, and Operations Research) Turkey project, with the invaluable support of mentors Canan Demir and Eylem Acart\u00FCrk. We would like to thank to Professor Pinar Ay, Department of Public Health, Marmara University School of Medicine, for her guidance with the statistics.
dc.identifier.citationYilmaz Yegit, C., Ergenekon, P., Yanaz, M., Ozturk Akar, N., Toktas Yavuz, F., Molla Kafi, H., ... & Karadag, B. (2025). The Association between Aminoglycoside Exposure and Ototoxicity in Children with Cystic Fibrosis. Respiration, 104(1), 48-57.
dc.identifier.doi10.1159/000541447
dc.identifier.endpage57
dc.identifier.issn00257931
dc.identifier.issue1
dc.identifier.pmid39299224
dc.identifier.scopus2-s2.0-85208555493
dc.identifier.scopusqualityQ1
dc.identifier.startpage48
dc.identifier.urihttp://dx.doi.org/10.1159/000541447
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6963
dc.identifier.volume104
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKarasu, Nesibe
dc.institutionauthoridNesibe Karasu / 0000-0002-8443-4660
dc.language.isoen
dc.publisherS. Karger AG
dc.relation.ispartofRespiration
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAminoglycosides
dc.subjectCystic Fibrosis
dc.subjectOtotoxicity
dc.titleThe Association between Aminoglycoside Exposure and Ototoxicity in Children with Cystic Fibrosis
dc.typeArticle

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