Yazar "Dehshahri, Ali" seçeneğine göre listele

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    Editing SOX genes by CRISPR-Cas: current insights and future perspectives
    (MDPI, 2021) Dehshahri, Ali; Biagioni, Alessio; Bayat, Hadi; Lee, E. Hui Clarissa; Hashemabadi, Mohammad; Samareh-Fekri, Hojjat; Zarrabi, Ali
    Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and its associated proteins (Cas) is an adaptive immune system in archaea and most bacteria. By repurposing these systems for use in eukaryote cells, a substantial revolution has arisen in the genome engineering field. In recent years, CRISPR-Cas technology was rapidly developed and different types of DNA or RNA sequence editors, gene activator or repressor, and epigenome modulators established. The versatility and feasibility of CRISPR-Cas technology has introduced this system as the most suitable tool for discovering and studying the mechanism of specific genes and also for generating appropriate cell and animal models. SOX genes play crucial roles in development processes and stemness. To elucidate the exact roles of SOX factors and their partners in tissue hemostasis and cell regener-ation, generating appropriate in vitro and in vivo models is crucial. In line with these premises, CRISPR-Cas technology is a promising tool for studying different family members of SOX transcription factors. In this review, we aim to highlight the importance of CRISPR-Cas and summarize the applications of this novel, promising technology in studying and decoding the function of different members of the SOX gene family. © 2021 by the authors. Li-censee MDPI, Basel, Switzerland.
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    Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticles
    (Mdpi, 2023) Ranjbar, Shahla; Emamjomeh, Abbasali; Sharifi, Fatemeh; Zarepour, Atefeh; Aghaabbasi, Kian; Dehshahri, Ali; Sepahvand, Azadeh Mohammadi
    Herbal chemicals with a long history in medicine have attracted a lot of attention. Flavonolignans and flavonoids are considered as two classes of the above-mentioned compounds with different functional groups which exhibit several therapeutic capabilities such as antimicrobial, anti-inflammatory, antioxidant, antidiabetic, and anticancer activities. Based on the studies, high hydrophobic properties of the aforementioned compounds limit their bioavailability inside the human body and restrict their wide application. Nanoscale formulations such as solid lipid nanoparticles, liposomes, and other types of lipid-based delivery systems have been introduced to overcome the above-mentioned challenges. This approach allows the aforementioned hydrophobic therapeutic compounds to be encapsulated between hydrophobic structures, resulting in improving their bioavailability. The above-mentioned enhanced delivery system improves delivery to the targeted sites and reduces the daily required dosage. Lowering the required daily dose improves the performance of the drug by diminishing its side effects on non-targeted tissues. The present study aims to highlight the recent improvements in implementing lipid-based nanocarriers to deliver flavonolignans and flavonoids.
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    Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin
    (Amer Chemical Soc, 2023) Madamsetty, Vijay Sagar; Vazifehdoost, Maryam; Alhashemi, Samira Hossaini; Davoudi, Hesam; Zarrabi, Ali; Dehshahri, Ali; Fekri, Hojjat Samareh
    Since the first report on the pharmacological activity of curcumin in 1949, enormous amounts of research have reported diverse activities for this natural polyphenol found in the dietary spice turmeric. However, curcumin has not yet been used for human application as an approved drug. The clinical translation of curcumin has been hampered due to its low solubility and bioavailability. The improvement in bioavailability and solubility of curcumin can be achieved by its formulation using drug delivery systems. Hydrogels with their biocompatibility and low toxicity effects have shown a substantial impact on the successful formulation of hydrophobic drugs for human clinical trials. This review focuses on hydrogel-based delivery systems for curcumin and describes its applications as anti-cancer as well as wound healing agents.
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    Photodynamic therapy for leishmaniasis: recent advances and future trends
    (Elsevier Science, 2021) Varzandeh, Mohammad; Mohammadinejad, Reza; Esmaeilzadeh-Salestani, Keyvan; Dehshahri, Ali; Zarrabi, Ali; Aghaei-Afshar, Abbas
    Leishmaniasis has infected more than 12 million people worldwide. The neglected tropical disease causing 20,000-30,000 deaths per year determined as a global health problem. The emergence of resistant parasites and serious side effects of the conventional therapies has led to the search for less toxic and non-invasive alternative treatments. Photodynamic therapy is a promising therapeutic strategy to produce reactive oxygen species for the treatment of leishmaniasis. In this regard, natural and synthetic photosensitizers such as curcumin, hypericin, 5-aminolevulinic acid, phthalocyanines, phenothiazines, porphyrins, chlorins and nanoparticles have been applied. In this review, the recent advances on using photodynamic therapy for treating Leishmania species have been reviewed.