Yazar "Eren, Makbule" seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe The comparison of efficacy and tolerability of two bowel preparation agents in children: polyethylene glycol vs sodium phosphate(DergiPark, 2020) Aydemir, Yusuf; Baris, Zeren; Yurttas, Gozde Nur; Yavuz, Asli; Eren, MakbuleAbstract: Adequate bowel cleansing with a good patient tolerability is important for high-quality and safe colonoscopy. We aimed to compare the efficacy and tolerability of an osmotic agent, polyethylene glycol (PEG) and a less frequently used stimulant agent, sodium phosphate (NP) for pediatric patients. We analyzed the records of pediatric patients who underwent colonoscopy and used either PEG or NP for bowel cleansing between January 2016 and December 2019. The patient tolerability of bowel preparation was assessed using a patient questionnaire that consisted of acceptance and adverse events, recording abdominal pain, nausea, vomiting, dizziness and severity of these symptoms. The quality of bowel preparation was assessed according to the Ottawa scale, including cleanliness and fluid quantity. The colonoscopic video records were retrospectively and blindly evaluated for Ottawa scale. There were a total of 145 patients (65 boys, 44.8%) with a mean age of 12.3±4.2 years. PEG was used in 93 patients (64.1%), while NP was used in 52 patients (35.9%). The mean age of the patients was significantly lower in PEG group (11.2±4.6 years) when compared to NP group (14.2±2.7 years) (p<0.0001). The patients who used PEG had significantly better tolerance without any complaints when compared to the patients who used NP (49/93 patients (52.7%) vs 14/52 patients (26.9%), respectively, p=0.003). Regarding the severity of symptoms in patients who had adverse events, the NP group had significantly more frequent moderate-severe side effects when compared to PEG group (15/52 patients (28.8%) vs 15/93 patients (16.1%), respectively, p=0.014). One of the children in NP group had severe hyperphosphatemia, which required fluid resuscitation. Regarding the efficacy of the preparations, 39/93 (41.9%) of the patients in PEG group had required wash and suctioning in any segments of the colon, this ratio was significantly lower in NP group (12/52 (23%)), (p=0.029). The Ottawa bowel preparation quality score in right colon and total Ottawa scale rating was significantly better in NP group when compared to PEG group (p=0.009 and 0.034, respectively). The Ottawa scores in mid and rectosigmoid colons were not significantly different between two groups. As conclusion, NP is more efficient in bowel cleansing when compared to PEG. But PEG had less frequent moderate-severe side effects compared to NP. Additionally, NP should be carefully used in selected cases where other bowel cleansing methods cannot be used, because of the severe side effects like hyperphosphatemia in children.Öğe Effect of Lactobacillus rhamnosus LGG and Bifidobacterium animalis subspecies lactis BB-12 combination on the duration of diarrhea and length of hospital stay in children with acute diarrhea in Turkey(DergiPark, 2020) Dinleyici, Ener Çağrı; Özen, Metehan; Dalgıç, Nazan; Yaşa, Olcay; Yazar, Ahmet Sami; Eren, MakbuleBackground Acute diarrhea continues to be a leading cause of morbidity and mortality worldwide. The main therapy for all individuals with dehydration caused by diarrhea is oral rehydration. Probiotics have been proposed as a complementary therapy in the treatment of acute diarrhea. We aim to evaluate the effect of a combination of Lactobacillus rhamnosus GG (LGG) with Bifidobacterium animalis subspecies lactis BB-12 (BB-12) on the duration of diarrhea and length of hospital stay in children with acute diarrhea. Methods A multicenter, randomized (240 children, 2:1 randomized for probiotic vs. control), single blind, hospitalbased clinical trial was performed in children (6 to 60 months) with acute watery diarrhea lasting more than 24 but less than 72 hours, requiring hospitalization. We enrolled children with clinical signs of mild to moderate dehydration. The children received conventional therapy with or without the combination of LGG and BB-12 (1 × 109 colony forming units for each) for 5 days. The primary endpoint was the duration of diarrhea (in hours), defined as the first normal stool according to the Bristol stool score (score < 5). Secondary outcome measures were duration of hospitalization (days) and percentage of children without diarrhea at 72 hours of intervention. Results In total, data from 218 of 240 children could be evaluated (150 in the probiotic group and 68 in the control group). The duration of diarrhea was significantly reduced in the LGG and BB-12 group compared to the control group (74.5 ± 40.8 hours vs. 98.4 ± 22.9 hours, P<0.001). The percentage of diarrhea-free children was significantly larger in the LGG and BB-12 group at 72 hours compared to the control (60% vs. 33.8%, P<0.001). Mean length of hospital stay was similar for both groups (5.03 ± 2.3 days vs. 5.25 ± 1.3 days, P>0.05). Conclusion This is the first clinical trial to test the combination of LGG and BB-12, and show its effects on diarrhea duration in children with acute infectious diarrhea. The duration of diarrhea was reduced by approximately 24 hours in the hospitalized children. Further randomized controlled clinical trials including outpatient cases with acute infectious diarrhea in addition to hospitalized cases should be conducted to assess the potential effects of the combination in more detail.Öğe Hematological parameters and leukocyte formulas in predicting celiac disease in children with iron deficiency anemia(GALENOS YAYINCILIK, 2021) Ozdemir, Zeynep Canan; Kar, Yeter Duzenli; Bektas, Polat Cengiz; Eren, Makbule; Bilgin, Muzaffer; Bor, OzcanObjective: Celiac disease (CD) is a systemic inflammatory disease associated with a number of hematological findings. The most common symptom other than the intestinal system is iron deficiency anemia (IDA). It is difficult to distinguish IDA that occurs in CD from nutritional IDA. In this study, the use of hematological parameters and leukocyte formulas, which are reported to be of diagnostic importance in inflammatory diseases, as a screening test in predicting CD in children with IDA was investigated. Methods: Forty-six children with CD and IDA, 46 children with nutritional IDA and 46 healthy children as a control group were included in the study. The patient files were examined retrospectively. The blood count parameters [Hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), mean platelet volume (MPV), platelet distribution width (PDW), erythrocyte, leukocyte, neutrophil, lymphocyte, platelet count] of the patients before starting iron therapy were recorded. Leukocyte formulas [neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), RDW/lymphocyte ratio (RLR)] were calculated. Results: There was no difference between the patient and control groups in terms of age and gender distribution (p>0.05). Hb, MCV, MCH, MCHC values of CD+IDA and IDA groups were lower than the values of the control group (p<0.001, for all), RDW, RLR, PLR values, and platelet count were higher than the values of the control group (p<0.001 and p<0.001; p<0.05 and p<0.01; p<0.05 and p<0.05; p<0.001 and p<0.05, respectively). Leukocyte, neutrophil, lymphocyte, erythrocyte counts, MPV, PDW, NLR were found to be similar in the patient and control groups (p>0.05 for all). There was no difference between the patient groups in terms of NLR, PLR, and RLR (p>0.05 for all). Conclusion: Our study showed that hematological parameters and leukocyte formulas are not useful in predicting CD in children with IDA.Öğe IL-15 gene polymorphism in celiac disease patients and their siblings(Turkish Journal of Gastroenterology, 2021) Kara, Yalcin; Eren, Makbule; Arslan, Serap; Cilingir, OguzBackground: Celiac disease (CD) is an immune-mediated enteropathy characterized by lifelong gluten intolerance. Interleukin-15 (IL15) is a proinflammatory cytokine that is considered a key component in the immune reaction triggered by gluten. Our aim of this study was to evaluate the influence of IL-15 gene polymorphisms on CD development and clinical presentation. Methods: The study was enrolled-with 90 CD patients (49 female/41 male, median years of age 11), their 38 siblings (20 female/18 male, median years of age 8), and 99 healthy controls (66 female/33 male, median years of age 13). Their demographic findings, symptoms, and signs histopathological grade, Human Leukocyte Antigen (HLA) types were recorded. IL-15 gene polymorphisms rs2857261, rs10519613, and rs1057972 were analyzed through PCR. Results: There was a significantly higher frequency of GG genotype in rs2857972 polymorphisms and TT genotype in rs1057972 polymorphisms in celiac families compared to controls [41% vs. 23% (P = .0008), 36% vs. 11% (P = .001), respectively]. Without considering their HLA status, there was not any difference between celiacs and healthy siblings. However, when stratified according to their HLADQ2 status, rs2857972 GG polymorphism was 1.5 times prominent in celiacs than siblings at homozygous state, whereas rs1057972 TT genotype was found to be 2.5 times prominent in celiac siblings at heterozygous state. There was no association between these polymorphisms and clinical presentation. Conclusion: rs2857972 GG and rs1057972 TT variants of IL 15 are more prominent in celiac families than controls. However, the impact of IL-15 gene polymorphism on CD development is dependent on HLADQ2 status.
