Hematological parameters and leukocyte formulas in predicting celiac disease in children with iron deficiency anemia
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
GALENOS YAYINCILIK
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Celiac disease (CD) is a systemic inflammatory disease associated with a number of hematological findings. The most common symptom other than the intestinal system is iron deficiency anemia (IDA). It is difficult to distinguish IDA that occurs in CD from nutritional IDA. In this study, the use of hematological parameters and leukocyte formulas, which are reported to be of diagnostic importance in inflammatory diseases, as a screening test in predicting CD in children with IDA was investigated. Methods: Forty-six children with CD and IDA, 46 children with nutritional IDA and 46 healthy children as a control group were included in the study. The patient files were examined retrospectively. The blood count parameters [Hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), mean platelet volume (MPV), platelet distribution width (PDW), erythrocyte, leukocyte, neutrophil, lymphocyte, platelet count] of the patients before starting iron therapy were recorded. Leukocyte formulas [neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), RDW/lymphocyte ratio (RLR)] were calculated. Results: There was no difference between the patient and control groups in terms of age and gender distribution (p>0.05). Hb, MCV, MCH, MCHC values of CD+IDA and IDA groups were lower than the values of the control group (p<0.001, for all), RDW, RLR, PLR values, and platelet count were higher than the values of the control group (p<0.001 and p<0.001; p<0.05 and p<0.01; p<0.05 and p<0.05; p<0.001 and p<0.05, respectively). Leukocyte, neutrophil, lymphocyte, erythrocyte counts, MPV, PDW, NLR were found to be similar in the patient and control groups (p>0.05 for all). There was no difference between the patient groups in terms of NLR, PLR, and RLR (p>0.05 for all). Conclusion: Our study showed that hematological parameters and leukocyte formulas are not useful in predicting CD in children with IDA.
Açıklama
Anahtar Kelimeler
Child, Celiac Disease, Iron Deficiency Anemia, Hematological Parameters, Leukocyte Formulas
Kaynak
JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
11
Sayı
2
Künye
Özdemir, Z. C., Düzenli Kar, Y., Bektaş, P. C., Eren, M., Bilgin, M., & Bör, Ö. (2021). Hematological Parameters and Leukocyte Formulas in Predicting Celiac Disease in Children with Iron Deficiency Anemia. Journal of Academic Research in Medicine, 11(2), 187–191.
