Hematological parameters and leukocyte formulas in predicting celiac disease in children with iron deficiency anemia

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dc.authoridMakbule Eren / 0000-0002-7105-7165en_US
dc.authorscopusidMakbule Eren / 7006788428
dc.authorwosidMakbule Eren / AAD-8138-2019
dc.contributor.authorOzdemir, Zeynep Canan
dc.contributor.authorKar, Yeter Duzenli
dc.contributor.authorBektas, Polat Cengiz
dc.contributor.authorEren, Makbule
dc.contributor.authorBilgin, Muzaffer
dc.contributor.authorBor, Ozcan
dc.date.accessioned2021-09-09T06:19:05Z
dc.date.available2021-09-09T06:19:05Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Celiac disease (CD) is a systemic inflammatory disease associated with a number of hematological findings. The most common symptom other than the intestinal system is iron deficiency anemia (IDA). It is difficult to distinguish IDA that occurs in CD from nutritional IDA. In this study, the use of hematological parameters and leukocyte formulas, which are reported to be of diagnostic importance in inflammatory diseases, as a screening test in predicting CD in children with IDA was investigated. Methods: Forty-six children with CD and IDA, 46 children with nutritional IDA and 46 healthy children as a control group were included in the study. The patient files were examined retrospectively. The blood count parameters [Hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), mean platelet volume (MPV), platelet distribution width (PDW), erythrocyte, leukocyte, neutrophil, lymphocyte, platelet count] of the patients before starting iron therapy were recorded. Leukocyte formulas [neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), RDW/lymphocyte ratio (RLR)] were calculated. Results: There was no difference between the patient and control groups in terms of age and gender distribution (p>0.05). Hb, MCV, MCH, MCHC values of CD+IDA and IDA groups were lower than the values of the control group (p<0.001, for all), RDW, RLR, PLR values, and platelet count were higher than the values of the control group (p<0.001 and p<0.001; p<0.05 and p<0.01; p<0.05 and p<0.05; p<0.001 and p<0.05, respectively). Leukocyte, neutrophil, lymphocyte, erythrocyte counts, MPV, PDW, NLR were found to be similar in the patient and control groups (p>0.05 for all). There was no difference between the patient groups in terms of NLR, PLR, and RLR (p>0.05 for all). Conclusion: Our study showed that hematological parameters and leukocyte formulas are not useful in predicting CD in children with IDA.en_US
dc.identifier.citationÖzdemir, Z. C., Düzenli Kar, Y., Bektaş, P. C., Eren, M., Bilgin, M., & Bör, Ö. (2021). Hematological Parameters and Leukocyte Formulas in Predicting Celiac Disease in Children with Iron Deficiency Anemia. Journal of Academic Research in Medicine, 11(2), 187–191.en_US
dc.identifier.doi10.4274/jarem.galenos.2021.46338en_US
dc.identifier.endpage191en_US
dc.identifier.issn2146-6505en_US
dc.identifier.issn2147-1894en_US
dc.identifier.issue2en_US
dc.identifier.startpage187en_US
dc.identifier.trdizinid462696en_US
dc.identifier.urihttps://doi.org/10.4274/jarem.galenos.2021.46338
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2030
dc.identifier.volume11en_US
dc.identifier.wosWOS:000691756600011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorEren, Makbule
dc.language.isotren_US
dc.publisherGALENOS YAYINCILIKen_US
dc.relation.ispartofJOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREMen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChilden_US
dc.subjectCeliac Diseaseen_US
dc.subjectIron Deficiency Anemiaen_US
dc.subjectHematological Parametersen_US
dc.subjectLeukocyte Formulasen_US
dc.titleHematological parameters and leukocyte formulas in predicting celiac disease in children with iron deficiency anemiaen_US
dc.title.alternativeDemir eksikliği anemisi olan çocuklarda çölyak hastalığını öngörmede hematolojik parametreler ve lökosit formüllerien_US
dc.typeReview Articleen_US

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