Improvement of photochemical and enzyme inhibition properties of new BODIPY compound by conjugation with cisplatin

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dc.authoridParham Taslimi / 0000-0002-3171-0633en_US
dc.authorscopusidParham Taslimi / 56658628800en_US
dc.authorwosidParham Taslimi / AAL-2788-2020en_US
dc.contributor.authorCan Karanlık, Ceren
dc.contributor.authorKaranlık, Gürkan
dc.contributor.authorTaslimi, Parham
dc.contributor.authorErdoğmuş, Ali
dc.date.accessioned2022-08-10T13:35:12Z
dc.date.available2022-08-10T13:35:12Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractIn this study, new BODIPY complexes were synthesized, characterized and investigated for their some metabolic enzyme inhibition and photophysicochemical properties. BODIPY central core unit was synthesized by using conventional method followed by Suzuki-Miyaura Cross-Coupling reaction. After converting the obtained compound into the diiodinated derivative in the presence of HIO3/I2, quaternization of BODIPY derivative was achieved with cisplatin [cis-PtCl(NO3)(NH3)2] over the pyridine segment. Characterizations of all intermediates and the target compound were determined by 1H-NMR, 13C-NMR and MS spectroscopic methods. The potentials of the synthesized compounds in photodynamic therapy applications were determined by calculating the fluorescence, singlet oxygen and photodegradation quantum yields. Also, all complexes were screened for human carbonic anhydrase I, II (hCAs I and II), acetylcholinesterase (AChE), butyryl cholinesterase (BChE), and ?-glucosidase inhibitory activities. Results indicated that all the synthesized complexes exhibited potent inhibitory activities against standard inhibitors, revealed by IC50 values. © 2022 Elsevier Ltden_US
dc.identifier.citationCan Karanlık, C., Karanlık, G., Taslimi, P., & Erdoğmuş, A. (2022). Improvement of photochemical and enzyme inhibition properties of new BODIPY compound by conjugation with cisplatin. Polyhedron, 225 doi:10.1016/j.poly.2022.116042en_US
dc.identifier.doi10.1016/j.poly.2022.116042en_US
dc.identifier.issn0277-5387en_US
dc.identifier.scopus2-s2.0-85134736626en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://doi.org/10.1016/j.poly.2022.116042
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3079
dc.identifier.wosWOS:000844046300003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTaslimi, Parham
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofPolyhedronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCholinesterasesen_US
dc.subjectBODIPYen_US
dc.subjectCisplatinen_US
dc.subjectEnzyme Inhibitionen_US
dc.subjectSinglet Oxygenen_US
dc.subjectα-Glucosidaseen_US
dc.titleImprovement of photochemical and enzyme inhibition properties of new BODIPY compound by conjugation with cisplatinen_US
dc.typeArticleen_US

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