First report of t(1;15)(q21;q11.2) and t(1;21)(q21;q11.2) anomalies in Burkitt Lymphoma

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dc.authoridSüreyya Bozkurt / 0000-0002-1765-9894en_US
dc.authorscopusidSüreyya Bozkurt / 55540860700
dc.authorwosidSüreyya Bozkurt / AAP-1146-2020
dc.contributor.authorBozkurt, Süreyya
dc.contributor.authorOkay, Mufide
dc.contributor.authorHaznedaroğlu, Celalettin İbrahim
dc.date.accessioned2021-10-13T06:34:04Z
dc.date.available2021-10-13T06:34:04Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBurkitt lymphoma (BL) is a highly aggressive B cell neoplasm characterized by t(8;14)(q24;q32) which involves the MYC gene. Sometimes, patients have additional cytogenetic anomalies beside t(8;14)(q24;q32) and these anomalies usually lead to more aggressive phenotype. The aim of this paper is to report two novel karyotypic abnormalities which give rise to tetrasomy 1q with an aggressive clinical course of BL. We present a 41-year-old woman with BL. In this patient, the t(1;15)(q21;q11) and t(1;21)(q21;q11.2) were found in the complex karyotype with the translocation of t(8;14)(q24;q32), which is a characteristic of BL. The t(1;15)(q21;q11.2) and t(1;21)(q21;q11.2) anomalies were reported for the first time according to the databases that we have investigated. In our case, the result of t(1;15)(q21;q11.2) and t(1;21)(q21;q11.2) was tetrasomy of chromosomes of 1q. Structural anomalies of chromosomes 1q could be seen in BL patients as additional cytogenetic anomalies and gain of chromosome of 1q usually associated with disease recurrence and poor prognosis. In our case, the patient died approximately 8 months after diagnosis, so her prognosis was poor, which was consistent with the literature. The candidate genes on chromosomes 1q which could be involved in tumorigenesis remain to be identified.en_US
dc.identifier.citationBozkurt, S., Okay, M. & Haznedaroglu, CI (2021). First report of t(1;15)(q21;q11.2) and t(1;21)(q21;q11.2) anomalies in Burkitt Lymphoma. KUWAIT MEDICAL JOURNAL 53 (3), 344-345.en_US
dc.identifier.endpage345en_US
dc.identifier.issn0023-5776en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage344en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2141
dc.identifier.volume53en_US
dc.identifier.wosWOS:000701389600019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBozkurt, Süreyya
dc.language.isoenen_US
dc.publisherKUWAIT MEDICAL ASSOCen_US
dc.relation.ispartofKUWAIT MEDICAL JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytogeneticen_US
dc.subjectRare Chromosomal Anomaliesen_US
dc.subjectRare Translocationsen_US
dc.titleFirst report of t(1;15)(q21;q11.2) and t(1;21)(q21;q11.2) anomalies in Burkitt Lymphomaen_US
dc.typeArticleen_US

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