Microwave-assisted hydrothermal green synthesis of selenium nanoparticles incorporated with hyaluronic acid methacrylate/gelatin methacrylate hydrogels for wound healing applications

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dc.authoridTorkay, Gülşah/0000-0002-6803-494X
dc.authoridKayin, Inci/0000-0003-1602-1140
dc.authoridBAL OZTURK, AYCA/0000-0002-6502-528X
dc.authorwosidTorkay, Gülşah/IUP-3797-2023
dc.authorwosidBAL OZTURK, AYCA/M-4472-2018
dc.contributor.authorNejati, Omid
dc.contributor.authorTisli, Busra
dc.contributor.authorYasayan, Gokcen
dc.contributor.authorZaman, Buse Tugba
dc.contributor.authorTorkay, Gulsah
dc.contributor.authorDonmez, Mustafa
dc.contributor.authorKayin, Inci
dc.date.accessioned2024-05-19T14:41:48Z
dc.date.available2024-05-19T14:41:48Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractWound healing is a topic of significant interest in current times, owing to the escalating incidence of chronic diseases associated with impaired healing, as well as the growing number of elderly individuals within the population. Amongst the various approaches for fabrication of wound healing dressings, the utilization of selenium-based nanoparticles has garnered considerable attention due to selenium's numerous advantages, including antioxidant, antiviral, antibacterial, and antifungal activities. With this perspective, we focused on the fabrication and characterization of hydrogels incorporated with selenium nanoparticles (SeNPs). In this work, we have developed a microwave-assisted hydrothermal synthesis strategy for synthesis of the SeNPs that employ non-toxic precursors, thereby reducing the risk of environmental toxicity and providing a cost-effective alternative to conventional chemical and hydrothermal methods. Subsequently, we have successfully incorporated SeNPs into hyaluronic acid methacrylate/gelatin methacrylate-based hydrogels. Hyaluronic acid and gelatin are selected to support the healing process further, and these polymers are methacrylated in order to further control mechanical properties of the hydrogel and improve the stability of the dressing. The nanoparticles and the nanoparticle-incorporated hydrogels were characterized by various techniques including Fourier transform infrared spectroscopy, UV-Vis spectroscopy, scanning electron microscopy, and dynamic light scattering instruments. Mechanical behaviors, swelling and degradation properties of the dressings were evaluated. Afterwards, we have conducted cell culture studies with SeNPs-loaded hydrogels to determine the efficacy of SeNPs in wound healing. According to experimental findings, in vitro scratch assay suggests that a hydrogel dressing containing SeNPs (HG-SeNp2) support the cell migration more compared to other samples incorporated with nanoparticles and to the control study at 24 h, and the wound closure percentage was found to be statistically significant compared with the control study. This dressing hold promise as effective wound dressings that can facilitate and expedite the process of wound healing.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [2210/A]; [1649B022101483]en_US
dc.description.sponsorshipGuel & scedil;ah Torkay would like to acknowledge the financial support from the Scientific and Technological Research Council of Turkey (TUBITAK) 2210/A General Domestic Graduate Scholarship Program (App No:1649B022101483).en_US
dc.identifier.doi10.1002/pen.26549
dc.identifier.endpage327en_US
dc.identifier.issn0032-3888
dc.identifier.issn1548-2634
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85178226741en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage316en_US
dc.identifier.urihttps://doi.org10.1002/pen.26549
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5160
dc.identifier.volume64en_US
dc.identifier.wosWOS:001111007800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPolymer Engineering and Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectGelatin Methacrylateen_US
dc.subjectGreen Synthesisen_US
dc.subjectHyaluronic Acid Methacrylateen_US
dc.subjectHydrogelen_US
dc.subjectMicrowave-Assisted Hydrothermal Synthesisen_US
dc.subjectSelenium Nanoparticlesen_US
dc.subjectWound Healingen_US
dc.titleMicrowave-assisted hydrothermal green synthesis of selenium nanoparticles incorporated with hyaluronic acid methacrylate/gelatin methacrylate hydrogels for wound healing applicationsen_US
dc.typeArticleen_US

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