Urinary trehalase activitiy in contrast-associated acute kidney injury

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dc.contributor.authorKovanci, B.
dc.contributor.authorDogan, H.
dc.contributor.authorOlgun, A.
dc.contributor.authorKural, A.
dc.contributor.authorYigit, Y.
dc.contributor.authorNeijman, S.T.
dc.date.accessioned2024-05-19T14:33:43Z
dc.date.available2024-05-19T14:33:43Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractOBJECTIVE: Contrast-associated acute kidney injury (CA-AKI) is the third most common cause of hospital-acquired AKI. Sensitive biomarkers can detect kidney injury early on because kidney damage begins immediately after the administration of a contrast medium. Due to its proximal tubule specificity, urinary trehalase can be a useful and early marker for detecting tubular damage. This study aimed to reveal the power of urinary trehalase activity in diagnosing CA-AKI. PATIENTS AND METHODS: This is a prospective, observational, and diagnostic validity study. The study was performed in an academic research hospital’s emergency department. Patients aged 18 years and over who underwent contrast-enhanced computed tomography in the emergency department were included in the study. Urinary trehalase activities were measured before and 12, 24, and 48 hours after the administration of a contrast medium. The primary outcome was the occurrence of CA-AKI, while the secondary outcomes were risk factors for CA-AKI, duration of hospital stay after contrast use, and the mortality rate in the hospital. RESULTS: A statistically significant difference between the CA-AKI group and the non-AKI group was found in the activities measured 12 hours after the administration of the contrast medium. Notably, the mean age of the patient group with CA-AKI was considerably higher than that of the non-AKI group. The risk of mortality was found to be remarkably more elevated in patients with CA-AKI. Further, there was a positive correlation between trehalase activity and HbA1c. In addition, a crucial correlation was found between trehalase activity and poor glycemic control. CONCLUSIONS: Urinary trehalase activity can be useful as a marker of acute kidney injuries due to proximal tubule damage. In the diagnosis of CA-AKI, especially the activity of trehalase in the 12th hour might be useful. © 2023 Verduci Editore s.r.l. All rights reserved.en_US
dc.identifier.doi10.26355/eurrev_202302_31363
dc.identifier.endpage1304en_US
dc.identifier.issn1128-3602
dc.identifier.issue4en_US
dc.identifier.pmid36876669en_US
dc.identifier.scopus2-s2.0-85149538040en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1298en_US
dc.identifier.urihttps://doi.org/10.26355/eurrev_202302_31363
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4317
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Editore s.r.len_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectContrast-Associated Acute Kidney İnjuryen_US
dc.subjectDiabetic Nephropathyen_US
dc.subjectPost-Contrast Acute Kidney İnjuryen_US
dc.subjectTrehalaseen_US
dc.titleUrinary trehalase activitiy in contrast-associated acute kidney injuryen_US
dc.typeArticleen_US

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