Frontal theta response in parkinson's disease during auditory and visual cognitive paradigms

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dc.authoridReyyan Uysal Kaba / 0000-0001-5021-8663
dc.authorwosidReyyan Uysal Kaba / ABG-7638-2020
dc.contributor.authorYıldırım, E.
dc.contributor.authorHanoğlu, L.
dc.contributor.authorAktürk, T.
dc.contributor.authorHelvacı Yılmaz, N.
dc.contributor.authorUysal Kaba, Reyyan
dc.contributor.authorRusen, E.
dc.contributor.authorGüntekin, B.
dc.date.accessioned2021-11-19T06:12:35Z
dc.date.available2021-11-19T06:12:35Z
dc.date.issued2018en_US
dc.departmentİstinye Üniversitesi, İnsan ve Toplum Bilimleri Fakültesi, Psikoloji Bölümüen_US
dc.description.abstractIntroduction: Cognitive Impairment in Parkinson’s disease could occur by the progression of the disease. Event-related theta responses in the frontal region is strongly connected with cognitive processes. Increase of theta response during increased cognitive load is a robust finding. The decrease theta phase-locking and theta power was found in the patient groups which had cognitive decline. The aim of the present study is to investigate the event-related theta responses in Parkinson Patients with and without cognitive deficits during auditory and visual cognitive paradigms. Methods: Three different group of Parkinson’s disease patients were included in the study. 15 PD patients without cognitive deficits, 23 PD patients with mild cognitive impairment (MCI), 11 PD patients with dementia, and 18 aged-matched healthy controls (HC) were included in the study. The mean of Mini Mental State Examination (MMSE) scores was 28,00±1,25 for the HC group, 26,80±1,90 for the PD group, 22,56±5,32 for the PD-MCI group, and 18,82±3,74 for the PD-Dementia group. EEG was recorded at 8 different frontal locations (F3-F4, F7-F8, FC3-FC4, and FT7-FT8). Auditory and visual oddball paradigms were applied during EEG recordings. Phase-locking analysis (Inter-trial coherence) and event related power spectrum were analyzed for theta (4-7 Hz) frequency band for all subject groups for both “target” and non-target” stimulations. Results: In accordance with the previous studies target stimulation elicited higher theta phase-locking and theta power than the non-target stimulation (p<0.05 for both comparisons). Group difference were significant, HC group had higher theta phase-locking and theta power than the PD-MCI group and PD-Dementia group. Furthermore, PD group had higher theta phase locking and theta power than the PD-Dementia group. There were no difference, between HC group and PD group and between PD-MCI group and PD-Dementia group. Discussion: The present study once more showed the essential role of frontal theta response during cognitive processes. Frontal theta responses were increased during “target “stimulation both in auditory and visual oddball paradigms. PD patients with cognitive deficits (both PD-MCI and PD-Dementia) had reduced frontal theta response in comparison to healthy controls. Furthermore, PD patients with dementia had reduced frontal theta response in comparison to PD patients without cognitive deficits.en_US
dc.identifier.citationYildirim, E., Hanoglu, L., Aktürk, T., Yilmaz, N. H., Kaba, R. U., Rusen, E., & Guntekin, B. (2018). Frontal theta response in parkinson's disease during auditory and visual cognitive paradigms. International Journal of Psychophysiology, 131, S81-S82.en_US
dc.identifier.doi10.1016/j.ijpsycho.2018.07.232en_US
dc.identifier.endpageS82en_US
dc.identifier.issn0167-8760en_US
dc.identifier.startpageS81en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijpsycho.2018.07.232
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2260
dc.identifier.volume131en_US
dc.identifier.wosWOS:000865650700224en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorUysal Kaba, Reyyan
dc.language.isoenen_US
dc.publisherScience Directen_US
dc.relation.ispartofInternational Journal of Psychophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleFrontal theta response in parkinson's disease during auditory and visual cognitive paradigmsen_US
dc.typeArticleen_US

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