Increased circulating interleukin-23 level in patients with sarcoidosis

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dc.contributor.authorKobak, Senol
dc.contributor.authorSemiz, Huseyin
dc.contributor.authorAkyildiz, Muhittin
dc.contributor.authorGokduman, Ayse
dc.contributor.authorAtabay, Tennur
dc.contributor.authorVural, Huseyin
dc.date.accessioned2024-05-19T14:46:35Z
dc.date.available2024-05-19T14:46:35Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: Sarcoidosis is a Th1-mediated chronic inflammatory disease characterized by non-caseating granulomas. Its pathogenesis is not yet clear, but the possible role of various proinflammatory cytokines is being discussed. Aim: This study aims to determine serum cytokine (IL-6, IL-12, IL-17, and IL-23) levels in patients with sarcoidosis, and to determine a possible correlation with clinical and laboratory findings of the disease. Material and method: Forty-four biopsy-proven sarcoidosis patients followed up at a single centre and 41 healthy volunteers were included in the study. Demographic, clinical, laboratory, and radiological data of all patients were recorded. Serum samples from the patients and the control group were taken and IL-6, IL-12, IL-17, IL-23 were measured by ELISA method. Results: Of the 44 sarcoidosis patients, 13(29.5%) were male and 31(70.5%) were female. Average patient age was 47.4 years, mean disease duration was 3.2 years. Twenty-one (47.7%) patients had erythema nodosum, three (6.8%) had uveitis, 40(90.9%) had arthralgia, 23(52.3%) had ankle arthritis, 15(34.1%) had enthesitis. Laboratory evaluation showed increased serum ACE levels in 24(54.5%) patients, increased serum calcium levels in 11 (25%) patients, increased serum D3 levels in 5(11.4%) patients, increased ESR and CRP levels in 22(50%) and 23(52.3%) patients, respectively. Compared with the control group higher serum IL-23 levels were found in the patients with sarcoidosis (p = .01). Serum IL-23 was associated with ankle arthritis (p = .02). Serum IL-6, IL-12, and IL-17 levels were similar in the sarcoidosis patients and the control group (p = .128, p = .212, p = .521 respectively). Conclusion: In our study, we found increased serum IL-23 in patients with sarcoidosis, while serum IL-6, IL-12, and IL-17 were detected as normal. Although our results are somewhat contradictory to other studies in the literature, the question should still be whether sarcoidosis is a Th1/Th17 disease. Multicentre studies are needed in this regard.(c) 2022 Elsevier Espan similar to a, S.L.U. and Sociedad Espan similar to ola de Reumatologi ' a y Colegio Mexicano de Reumatologi ' a. All rights reserved.en_US
dc.identifier.doi10.1016/j.reuma.2022.11.007
dc.identifier.endpage481en_US
dc.identifier.issn1699-258X
dc.identifier.issn1885-1398
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85151685683en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage478en_US
dc.identifier.urihttps://doi.org10.1016/j.reuma.2022.11.007
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5553
dc.identifier.volume19en_US
dc.identifier.wosWOS:001102488000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Espana Sluen_US
dc.relation.ispartofReumatologia Clinicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectSarcoidosisen_US
dc.subjectSerum Cytokinesen_US
dc.subjectIncreased Il-23 Levelen_US
dc.titleIncreased circulating interleukin-23 level in patients with sarcoidosisen_US
dc.typeArticleen_US

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