Safety and efficacy of Amplatzer duct occluder II and konar-MF™ VSD occluder in the closure of perimembranous ventricular septal defects in children weighing less than 10 kg

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dc.authoridBaykan, Ali/0000-0002-6760-3936
dc.authorwosidKaradeniz, Cem/W-2159-2017
dc.authorwosidÖzdemir, Rahmi/GSJ-3472-2022
dc.authorwosidBaykan, Ali/AAV-4783-2020
dc.contributor.authorYildiz, Kaan
dc.contributor.authorNarin, Nazmi
dc.contributor.authorOksuz, Sedef
dc.contributor.authorOzdemir, Rahmi
dc.contributor.authorPamukcu, Ozge
dc.contributor.authorBaykan, Ali
dc.contributor.authorOzyurt, Abdullah
dc.date.accessioned2024-05-19T14:50:20Z
dc.date.available2024-05-19T14:50:20Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractIntroduction: Device closure of perimembranous ventricular septal defects (pmVSD) is a successful off-label treatment alternative. We aim to report and compare the outcomes of pmVSD closure in children weighing less than 10 kg using Amplatzer Duct Occluder II (ADOII) and Konar-MF VSD Occluder (MFO) devices.Methods: Retrospective clinical data review of 52 children with hemodynamically significant pmVSD, and sent for transcatheter closure using ADOII and MFO, between January 2018 and January 2023. Baseline, procedural, and follow-up data were compared according to the implanted device.Results: ADOII devices were implanted in 22 children with a median age of 11 months (IQR, 4.1-14.7) and weight of 7.4 kg (IQR, 2.7-9.7). MFO devices were implanted in 30 children with a median age of 11 months (IQR, 4.8-16.6) and weight of 8 kg (IQR, 4.1-9.6). ADOII were implanted (retrograde, 68.1%) in defects with a median left ventricular diameter of 4.6 mm (IQR, 3.8-5.7) and right ventricular diameter of 3.5 mm (IQR, 3.1-4.9) while MFO were implanted (antegrade, 63.3%) in defects with a median left ventricular diameter of 7 mm (IQR, 5.2-11.3) (p > 0.05) and right ventricular diameter of 5 mm (IQR, 2.0, 3.5-6.2) (p < 0.05). The procedural and fluoroscopy times were shorter with the MFO device (p < 0.05). On a median follow-up of 41.2 months (IQR, 19.7-49.3), valvular insufficiency was not observed. One 13-month-old child (6.3 kg) with ADOII developed a complete atrioventricular heart block (CAVB) six months postoperative and required pacemaker implantation. One 11-month-old child (5.9 kg) with MFO developed a CAVB 3 days postoperative and the device was removed. At 6 months post-procedure, only one child with MFO still experiences a minor residual shunt. There was one arterio-venous fistula that resolved spontaneously.Conclusion: Both the MFO and ADOII are effective closure devices in appropriately selected pmVSDs. CAVB can occur with both devices. The MFO is inherently advantageous for defects larger than 6 mm and subaortic rims smaller than 3 mm. In the literature, our series represents the first study comparing the mid-term outcomes of MFO and ADOII devices in children weighing less than 10 kg.en_US
dc.description.sponsorshipThe author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.en_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.3389/fcvm.2023.1255808
dc.identifier.issn2297-055X
dc.identifier.pmid38094116en_US
dc.identifier.urihttps://doi.org10.3389/fcvm.2023.1255808
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5675
dc.identifier.volume10en_US
dc.identifier.wosWOS:001124436400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Cardiovascular Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectVentricular Septal Defecten_US
dc.subjectTranscatheter Closureen_US
dc.subjectWeight >10 Kgen_US
dc.subjectAmplatzer Ducten_US
dc.subjectKonar-Multi Functional Occluderen_US
dc.titleSafety and efficacy of Amplatzer duct occluder II and konar-MF™ VSD occluder in the closure of perimembranous ventricular septal defects in children weighing less than 10 kgen_US
dc.typeArticleen_US

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