Effects of cannabinoid and vanilloid receptor antagonists on nicotine induced relaxation response enhancement in rabbit corpus cavernosum

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dc.authoridYusuf Sarıoğlu / 0000-0002-9227-365Xen_US
dc.authorscopusidYusuf Sarıoğlu / 7003713314
dc.authorwosidYusuf Sarıoğlu / DRN-8389-2022
dc.contributor.authorVural, Ismail Mert
dc.contributor.authorOzturk Fincan, Gokce Sevi
dc.contributor.authorKoc, Derya Sebile
dc.contributor.authorOkcay, Yagmur
dc.contributor.authorAskin, Celil Ilker
dc.contributor.authorKibar, Ayse Kubra
dc.contributor.authorIlhan, Sevil Ozger
dc.contributor.authorSarıoğlu, Yusuf
dc.date.accessioned2022-06-07T08:44:44Z
dc.date.available2022-06-07T08:44:44Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: Endocannabinoids and nicotine regulate the neurotransmitter release in different central and peripheral synapses. Various studies in the literature demonstrate the interaction between endocannabinoid and nicotinic systems, especially in the central nervous system. The interaction between nicotinic and endocannabinoid systems was investigated in this study. We aimed to show the effects of cannabinoid and vanilloid receptor antagonists on nicotine-induced relaxation response increases in rabbit corpus cavernosum. Materials and methods: From a total of seven male albino rabbits, three or four equal strips were cut from each corpus cavernosum and inserted in isolated organ baths. Tissues were contracted with phenylephrine (3×10-5 M). After contraction reached a plateau, strips were stimulated with EFS, and with the stabilization of EFS relaxation responses, 10-4 M of nicotine was administered to tissues. After that, in order to investigate the effects of AM251 (CB1 antagonist), AM630 (CB2 inverse agonist) or capsazepine (a vanilloid receptor antagonist) were given to different tissues, after the resting period. Results: Nicotine (10-4 M) increased the EFS-induced relaxation responses (14.60%±2.94%, P<0.05). AM630 decreased the enhancement of nicotine-induced EFS relaxation responses (nicotine 10-4 M enhancement: 17.16%±3.19%; nicotine 10-4 M enhancement in the presence of AM630 10-6 M: 4.44%±3.43% P<0.05; n=6), whereas effects of AM251 and capsazepine were not significant. Conclusion: In the present study, nicotine increased the amplitudes of EFS-induced relaxation responses probably via nicotinic acetylcholine receptors located on the nitrergic nerves of the corpus cavernosum. We showed the role of cannabinoid-like endo-ligands in nicotine-induced enhancement via CB2 receptors but not CB1 and VR1 receptors.en_US
dc.identifier.citationVural IM, Ozturk Fincan GS, Koc DS, Okcay Y, Askin CI, Kibar AK, Ilhan SO, Sarioglu Y. Effects of cannabinoid and vanilloid receptor antagonists on nicotine induced relaxation response enhancement in rabbit corpus cavernosum. Iran J Basic Med Sci. 2022 Apr;25(4):514-519. doi: 10.22038/IJBMS.2022.62222.13772. PMID: 35656074; PMCID: PMC9150803.en_US
dc.identifier.doi10.22038/IJBMS.2022.62222.13772en_US
dc.identifier.endpage519en_US
dc.identifier.issn2008-3866en_US
dc.identifier.issue4en_US
dc.identifier.pmid35656074en_US
dc.identifier.startpage514en_US
dc.identifier.urihttp://doi.org/10.22038/IJBMS.2022.62222.13772
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2833
dc.identifier.volume25en_US
dc.identifier.wosWOS:000793720800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSarıoğlu, Yusuf
dc.language.isoenen_US
dc.relation.ispartofIranian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCannabinoid Receptorsen_US
dc.subjectEndocannabinoidsen_US
dc.subjectNicotineen_US
dc.subjectPenile Erectionen_US
dc.subjectSmooth Muscleen_US
dc.titleEffects of cannabinoid and vanilloid receptor antagonists on nicotine induced relaxation response enhancement in rabbit corpus cavernosumen_US
dc.typeArticleen_US

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