Comparison of weight-based versus standard dosing of tranexamic acid for blood loss and transfusion amount in knee arthroplasty without tourniquet

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dc.authoridÇağatay Öztürk / 0000-0003-3133-206Xen_US
dc.authoridGürkan Gümüşsuyu / 0000-0001-8408-9521
dc.authorscopusidÇağatay Öztürk / 8230555600
dc.authorscopusidGürkan Gümüşsuyu / 55354167600
dc.authorwosidÇağatay Öztürk / FSD-8657-2022en_US
dc.authorwosidGürkan Gümüşsuyu / EXL-8041-2022
dc.contributor.authorGüler, Olcay
dc.contributor.authorÇarkçı, Engin
dc.contributor.authorÇerçi, Mehmet Halis
dc.contributor.authorGümüşsuyu, Gürkan
dc.contributor.authorÖztürk, Çağatay
dc.date.accessioned2022-06-09T13:48:42Z
dc.date.available2022-06-09T13:48:42Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, İlk ve Acil Yardım Bölümüen_US
dc.description.abstractThe aim of the study is to compare weight-based versus standard dosing of intravenous (IV) tranexamic acid (TXA) for blood loss and transfusion amount in total knee arthroplasty (TKA) without a tourniquet. A total of 99 patients were divided into two groups: Group 1 (standard): 1 g of IV TXA 30 min before skin incision, and 1 g at postoperative 30 min and 3 h. Group 2 (weight-based): 10 mg/kg IV TXA 30 min before the skin incision, and 10 mg/kg at postoperative 30 min, and 3 h. Hemoglobin levels, before, and 1, and 2 days after the operation, postoperative amount of decrease in hemoglobin levels, and amount of erythrocyte transfusion were recorded. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Knee Society Score (KSS) were applied in the evaluation of TKA results preoperatively, and at 1., 3., 6., and 12. months, postoperatively. In both study groups, hemoglobin levels in male patients dropped significantly more deeply than female patients. Also, in both study groups, hemoglobin levels were significantly lower in patients with comorbid illnesses. A statistically significant difference was not detected between both groups in terms of pre-and postoperative WOMAC scores, KSS knee scores, and KSS function scores. Our study showed that standard and weight-based dosing of IV TXA treatments were similar in efficacy and safety. Both treatments reduce blood loss and the need for transfusion. Also, there was no significant difference in terms of reliability between two groups.en_US
dc.identifier.citationGuler, O., Çarkcı, E., Halis Çerci, M., Gümüşsuyu, G., Öztürk, Ç. (2022). Comparison of weight-based versus standard dosing of tranexamic acid for blood loss and transfusion amount in knee arthroplasty without tourniquet. Acta Orthopaedica Belgica 88(1), 53–60.en_US
dc.identifier.doi10.52628/88.1.08en_US
dc.identifier.endpage60en_US
dc.identifier.issn0001-6462en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85129423700en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.52628/88.1.08
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2859
dc.identifier.volume88en_US
dc.identifier.wosWOS:000796390900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGümüşsuyu, Gürkan
dc.institutionauthorÖztürk, Çağatay
dc.language.isoenen_US
dc.publisherACTA MEDICA BELGICAen_US
dc.relation.ispartofACTA ORTHOPAEDICA BELGICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKnee Arthroplastyen_US
dc.subjectTranexamic Aciden_US
dc.subjectStandard Dosingen_US
dc.subjectWeight-Based Dosingen_US
dc.subjectBlood Losstransfusionen_US
dc.titleComparison of weight-based versus standard dosing of tranexamic acid for blood loss and transfusion amount in knee arthroplasty without tourniqueten_US
dc.typeArticleen_US

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