Current Use of sodium glucose co-transporter 2 inhibitors in heart failure therapy
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish society of cardiology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) inhibit urinary glucose and sodium reabsorption in the proximal tubule of the nephron and result in glucosuria, natriuresis and diuresis. In patients with T2DM who have atherosclerotic cardiovascular (CV) disease or CV risk factors, SGLT2is is have been shown to reduce major CV events and heart failure (HF) hospitalization. The greatest and most consistent effect of SGLT2is in these trials was found to be reduction in HF hospitalization, which raised the possibility of clinical benefit of SGLT2i in HF patients. In DAPA-HF and EMPEROR-Reduced trials in heart failure with reduced ejection fraction (HFrEF) patients with or without T2DM, SGLT2İs, dapagliflozin and empagliflozin treatment on top of standard HF therapy has been shown to have clear clinical benefit in reducing primary endpoint of CV mortality or HF hospitalization and improving quality of life. Recently published EMPEROR-Preserved and DELIVER trials showed that SGLT2is were also very effective in the treatment of heart failure with preserved ejection fraction (HFpEF) (EF >40%). Furthermore, SGLT2is have also been shown to have potential in improving clinical outcomes in hospitalized acute HF patients in EMPULSE and DICTATE-AHF trials. All of this evidence has changed guidelines recommended therapies, not only for HFrEF but also for HFpEF treatment. The aim of this article is to provide a comprehensive overview focused on the role of SGLT2i in the treatment of HF based on the recent evidence.
Açıklama
Anahtar Kelimeler
Diabetes Mellitus, Heart Failure, SGLT2 Inhibitors
Kaynak
Türk kardiyoloji derneği arşivi
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
52
Sayı
6
Künye
Çavuşoğlu, Y., Altay, H., Çelik, A., Güvenç, T. S., Kılıçarslan, B., Nalbantgil, S., ... & Yılmaz, M. B. (2024). Current Use of Sodium Glucose Co-transporter 2 Inhibitors in Heart Failure Therapy. Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir, 52(6), 429-454.
